3-(3-vinylphenyl)propionic acid | 1352089-94-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-(3-vinylphenyl)propionic acid
• 英文别名: 3-(3-Ethenylphenyl)propanoic acid
• CAS: 1352089-94-1
• 化学式: C₁₁H₁₂O₂
• 分子量: 176.215
• InChiKey: LCORRWMXZQXDNO-UHFFFAOYSA-N

物化性质

• 沸点：
  314.9±11.0 °C(Predicted)
• 密度：
  1.105±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-乙烯基苯硼酸 、 丙烯酸 在 [Rh(OH)(cod)]2 、 水 作用下， 反应 16.0h， 以72%的产率得到3-(3-vinylphenyl)propionic acid
  参考文献：
  名称：

  Rhodium(I)-Catalyzed 1,4-Addition of Arylboronic Acids to Acrylic Acid in Water: One-Step Preparation of 3-Arylpropionic Acids

  摘要：

  报告了一种通过铑催化芳基硼酸与丙烯酸的 1,4- 加成一步制备 3-芳基丙酸的实用方法。该方法适用于多种芳基硼酸，在以水为最佳反应介质的条件下，具有广泛的官能团耐受性。

  DOI：

  10.1055/s-0030-1260319

文献信息

• Styrenyl derivative compounds for treating ophthalmic diseases and disorders
  申请人：Acucela Inc.

  公开号：US10201545B2

  公开（公告）日：2019-02-12

  The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

  本发明一般涉及治疗神经退行性疾病和失调，特别是眼科疾病和失调的组合物和方法。本发明提供了苯乙烯基衍生物化合物，包括但不限于二苯乙烯基衍生物化合物，以及包含这些化合物的组合物，可用于治疗和预防眼科疾病和失调，包括老年性黄斑变性（AMD）和Stargardt病。
• TRANSITION METAL CHELATING BEADS
  申请人：Roche Diagnostics Operations, Inc.

  公开号：US20220009963A1

  公开（公告）日：2022-01-13

  The present invention relates to a complex comprising a transition metal cation (i); a ligand (ii) comprising at least one chelating group, preferably from 1 to 4 chelating groups, more preferred 2 or 3 chelating groups, wherein the chelating group(s) is/are selected from hydroxamate group —N(O″)—C(═O)—R, catechol ate group, carboxyl ate group, partly or totally protonated forms of these chelating groups and mixtures of these chelating groups and/or their partly or totally protonated forms, wherein R is hydrogen or a C1 to C5 alkyl group; and a magnetic bead (iii); wherein the magnetic bead (iii) and the ligand (ii) are covalently bonded. The invention also relates to the use of the complex for reduction of the content of at least one phosphor-oxy-substance, which preferably comprises a structural element —O—P(O″)(═O)—O— within its structure, in a fluid sample, as well as to a method for decreasing the content of at least one phosphor-oxy-substance, preferably a phospholipid, in a fluid sample, comprising a step of adding the complex. The invention further relates to a supernatant obtained or obtainable from this method and to the use of a supernatant obtained or obtainable from the method for qualitative and/or quantitative determination of at least one analyte in said supernatant. Furthermore, the invention relates to a method for qualitative and/or quantitative determination of at least one analyte in a fluid sample and to a method for determining the kind and/or amount of at least one phosphor-oxy-substance in a fluid sample.