3,4-dimethyl-2H-chromene | 16982-87-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3,4-dimethyl-2H-chromene
• 英文别名: 3,4-Dimethyl-2H-1-benzopyran
• CAS: 16982-87-9
• 化学式: C₁₁H₁₂O
• 分子量: 160.216
• InChiKey: TXUUTWRRPKVRMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-(1-methylethenyl)-2-[(2-methylprop-2-en-1-yl)oxy]benzene 在 [RuCl₂(CHPh)(C₃H₄N₂(C₆H₂Me₃)2)(C₃Cl₂N₂(iPr)(Me))] 作用下， 以 甲苯 为溶剂， 反应 20.0h， 以99%的产率得到3,4-dimethyl-2H-chromene
  参考文献：
  名称：

  [（NHC）（NHCewg）RuCl2（CHPh）]配合物与修饰的NHCewg配体进行高效的环封闭易位，从而导致四取代的烯烃

  摘要：

  咪唑鎓盐（NHC EWG ⋅ HCl中）与在4,5位上的电子可变取代基（H，H或Cl，Cl或H，NO 2或CN，CN）和位可变取代基的1,3-位（ME ，Me或Et，Et或i Pr，i Pr或Me，i Pr）被合成并转化为各自的[AgI（NHC）ewg ]配合物。[（NHC）RuCl 2（CHPh）（py）2 ]与[AgI（NHC ewg）]配合物的反应提供了各自的[（NHC）（NHC ewg）RuCl 2（CHPh）]络合物，收率极高。研究了此类络合物在开环复分解（RCM）反应中产生四取代烯烃的催化活性。为了获得定量的底物转化率，催化剂在80°C下甲苯中的催化剂负载量为0.2–0.5 mol％就足够了。在此类RCM反应中具有最佳催化活性和最快引发速率的配合物具有NHC ewg基团，该基团带有1,3-Me，i Pr和4,5-Cl，Cl取代基，可以从该化合物中以95％的分离产率合成钌前体。要

  DOI：

  10.1002/chem.200903275

文献信息

• HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
  申请人：Nishino Taito

  公开号：US20120128640A1

  公开（公告）日：2012-05-24

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R6 and R 7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.

  提供一种用于改善基因治疗中将基因转移至造血干细胞以治疗各种疾病的血液干细胞和/或造血祖细胞扩张剂。该扩张剂包含由式(I)表示的化合物（其中X、Y、Z、Ar1、R1、R2、R3、R4、R5、R6和R7如描述中所定义）、该化合物的互变异构体、前药或药学上可接受的盐或其溶剂，能够扩张血液干细胞和/或造血祖细胞。
• METHOD FOR EXPANDING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND
  申请人：Nishino Taito

  公开号：US20100266556A1

  公开（公告）日：2010-10-21

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various hematopoietic disorders is provided. A method for expanding hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises culturing hematopoietic stem cells and/or hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) (wherein X, Y, X, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.
• METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS
  申请人：The UNIVERSITY OF TOKYO

  公开号：US20140227780A1

  公开（公告）日：2014-08-14

  An agent for inducing production of megakaryocytes and/or platelets from pluripotent stem cells which is useful for treatment of disease accompanied by a decrease in platelets is provided. A method for producing megakaryocytes and/or platelets, including separating hematopoietic progenitor cells from the septal cells in sac-like structures produced by pluripotent stem cells, and culturing the hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) where R 1 to R 7 , W, X, Y, Z, Ar 1 and n are as defined in the description to differentiate them into megakaryocytes and/or platelets.
• US9328085B2
  申请人：——

  公开号：US9328085B2

  公开（公告）日：2016-05-03
• US9527828B2
  申请人：——

  公开号：US9527828B2

  公开（公告）日：2016-12-27