2(1H)-Anthracenone | 108121-79-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2(1H)-Anthracenone
• 英文别名: 1H-anthracen-2-one
• CAS: 108121-79-5
• 化学式: C₁₄H₁₀O
• 分子量: 194.23
• InChiKey: WIGJKQWSXRGQBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] TRICYCLIC BENZOPYRAN COMPOUND AS ANTI-ARRHYTHMIC AGENTS<br/>[FR] COMPOSE DE BENZOPYRANNE TRICYCLIQUE EN TANT QU'AGENTS ANTI-ARRYTHMIQUES
  申请人：NISSAN CHEMICAL IND LTD

  公开号：WO2005090357A1

  公开（公告）日：2005-09-29

  This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R1 and R2 are independently of each other hydrogen atom, C1-6alkyl group or C6-14aryl group, R3 is hydrogen atom or C1-6alkylcarbonyloxy group, or together with R4 forms a bond, R4 is hydrogen atom, or together with R3 forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R5 is hydrogen atom or C1-6alkyl group, R6 is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, amino group, C1-6alkylamino group, di-C1-6alkylamino group, C6-14arylamino group, C2-9heteroarylamino group, C6-14aryl group, C2-9heteroaryl group or C2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.

  本发明涉及公式（I）或（II）的苯并吡喁衍生物，或其药学上可接受的盐，其中R1和R2分别是氢原子、C1-6烷基或C6-14芳基，R3是氢原子或C1-6烷基羰氧基，或与R4一起形成键，R4是氢原子，或与R3一起形成键，m是0到4的整数，n是0到4的整数，V是单键，CR7R8，NR9，O，S，SO或SO2，R5是氢原子或C1-6烷基，R6是氢原子，C1-6烷基，C3-8环烷基，C3-8环烯基，氨基，C1-6烷基氨基，二C1-6烷基氨基，C6-14芳基氨基，C2-9杂芳基氨基，C6-14芳基，C2-9杂芳基或C2-9杂环烷基，A是与苯环融合的5、6或7成员环，作为环的组成原子，氧原子、氮原子或硫原子可以单独或组合地包含在其中，环中的不饱和键数为1、2或3，包括与苯环融合的不饱和键，构成环的碳原子可以是羰基或硫代羰基。这些化合物可用作抗心律失常药物。
• Method for preparing light-absorbing polymeric compositions
  申请人：——

  公开号：US20040195552A1

  公开（公告）日：2004-10-07

  The present invention recites a method comprising reacting in a solvent in the presence of a base a) at least one diacidic monomer comprising about 1 to 100 mole % of at least one light-absorbing monomer having a light absorption maximum between about 300 nm and about 1200 nm and 99-0 mole % of a non-light absorbing monomer which does not absorb significant light at wavelengths above 300 nm or has a light absorption maximum below 300 nm, with b) an organic compound of Formula II X—B—X 1 wherein B is a divalent organic radical to form a light absorbing composition comprising a mixture of a polymer having the formula 1 and a cyclic compound having the general formula 2 wherein B is as defined above; n is at least 2, m is 1, 2, 3 or 4 and A comprises the residue of a diacidic monomer comprising about 1 to 100 mole % of at least one light-absorbing monomer having a light absorption maximum between about 300 nm and about 1000 nm and wherein the remaining portion of A comprises the residue of a non-light absorbing monomer which does not absorb significant light at wavelengths above 300 nm or has a light absorption maximum below 300 nm.

  本发明涉及一种方法，包括在溶剂中，在碱的存在下反应：a）至少一种二酸单体，其中包括约1至100摩尔％的至少一种具有在300nm至1200nm之间的光吸收最大值的光吸收单体和99-0摩尔％的不吸收在300nm以上波长处的显著光或具有在300nm以下的光吸收最大值的非光吸收单体；b）式IIX-B-X1的有机化合物，其中B是二价有机基团，以形成一种光吸收组合物，该组合物包括具有式1的聚合物和具有一般式2的环状化合物，其中B如上所定义；n至少为2，m为1、2、3或4，A包括约1至100摩尔％的至少一种具有在300nm至1000nm之间的光吸收最大值的光吸收单体的残基，其中A的其余部分包括不吸收在300nm以上波长处的显著光或具有在300nm以下的光吸收最大值的非光吸收单体的残基。
• Photoactivators
  申请人：The Procter & Gamble Company

  公开号：US20150210960A1

  公开（公告）日：2015-07-30

  Photoactivators comprise a photoactive moiety and a hydrophilic moiety. The photoactivators preferably comprise less than about 35%, by weight of the photoactivator, of the photoactive moiety. The photoactivators can be activated to a photo-excited state by excitation with incident radiation of a wavelength between about 350 nm and 750 nm, preferably between about 350 nm and about 420 nm. The photoactivators further encompass those having certain chemical formulations.

  光活化剂包括光活性基团和亲水基团。光活化剂最好包含少于其重量的约35％的光活性基团。光活化剂可以通过激发波长在大约350nm和750nm之间（最好在大约350nm和大约420nm之间）的入射辐射而激活为光激发态。光活化剂还包括具有特定化学配方的化合物。
• Drug dispensing wound dressing
  申请人：THERMEDICS, INC.

  公开号：EP0184233A2

  公开（公告）日：1986-06-11

  The disclosed wound dressings have a drug dispersed throughout a polyurethane matrix that is the reaction product of: (A) An isocyanate terminated prepolymer formed by reaction of isophorone diisocyanate and a macroglycol and (B) a monomer containing hydroxyl and vinyl groups. The reaction product is a vinyl terminated polyurethane oligomer which is liquid at room temperature and which may be readily admixed with a pharmacoactive substance and a photosensitizer, formed into a film and cured by exposure to UV light without release of heat. In the most preferred embodiments the foregoing oligomer is codissolved in an organic solvent with a polyurethane polymer which is the reaction product of: dicyclohexyl methane diisocyanate; a polytetramethylene ether polyol having a molecular weight in the range of 1000-3000 Daltons; and 1,4-butane diol. That solution is then admixed with the pharmacoactive agent, formed into a film and cured.

  所公开的伤口敷料在聚氨酯基质中分散有药物，聚氨酯基质是下列物质的反应产物： (A) 异佛尔酮二异氰酸酯和大环二醇反应形成的异氰酸酯端预聚物和 (B) 含羟基和乙烯基的单体。反应产物为乙烯基端聚氨酯低聚物，在室温下呈液态，可与药效物质和光敏剂混合，形成薄膜，并通过紫外光照射固化而不释放热量。 在最优选的实施方案中，前述低聚物在有机溶剂中与聚氨酯聚合物共同溶解，后者是以下反应的产物： 二环己基甲烷二异氰酸酯； 分子量在 1000-3000 道尔顿范围内的聚四亚甲基醚多元醇；和 1,4-丁烷二醇。 然后将该溶液与药剂混合，制成薄膜并固化。
• Anisotropic wound dressing
  申请人：THERMEDICS, INC.

  公开号：EP0199857A1

  公开（公告）日：1986-11-05

  An anisotropic wound dressing comprised of a knitted reinforcing fabric which is sandwiched between a crosslinked aliphatic polyurethane. The wound dressing is fabricated by dipping the fabric into a polyurethane-forming coating solution to form a thin film which coats the fibers of the fabric and fills the interstices with a film or layer. The film which coats the fabric is cured by ultraviolet radiation and one side of the film is coated with pressure sensitive adhesive to form a wound dressing. In the most preferred embodiments, the knitted reinforcing fabric is an anisotropic fabric formed with a basic stitch construction to create equally spaced and sized hexagonal interstices. Because of the fabric reinforcement, the resulting oxygen permeable product can be made thin, and yet be anisotropic and strong. The resulting product does not wrinkle easily and holds its shape so it is also easily applied.

  一种各向异性伤口敷料，由夹在交联脂肪族聚氨酯之间的针织加固织物组成。伤口敷料的制作方法是将织物浸入聚氨酯形成的涂层溶液中，形成一层薄膜，包裹住织物的纤维，并在间隙中填充一层薄膜或层。包裹织物的薄膜通过紫外线辐射固化，薄膜的一面涂上压敏胶，形成伤口敷料。在最优选的实施方案中，针织加固织物是一种各向异性的织物，采用基本的缝合结构，形成等间距和等大小的六边形间隙。由于织物的加固作用，透氧产品可以做得很薄，但却具有各向异性和强度。制成的产品不易起皱，并能保持形状，因此也易于使用。