N-Benzyl-N-naphthalen-2-yl-isonicotinamide | 431894-54-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-Benzyl-N-naphthalen-2-yl-isonicotinamide
• 英文别名: N-benzyl-N-naphthalen-2-ylpyridine-4-carboxamide
• CAS: 431894-54-1
• 化学式: C₂₃H₁₈N₂O
• 分子量: 338.409
• InChiKey: CCGOWCSNLFQUBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• HETEROCYCLIC AMIDES FOR USE AS PHARMACEUTICALS
  申请人：Arista Luca

  公开号：US20100261758A1

  公开（公告）日：2010-10-14

  Compounds of Formula (I) wherein R 1 is aryl, cyclohexyl or heterocyclyl, or (C 1-4 )alkyl substituted by aryl, cyclohexyl or heterocyclyl, R 2 is defined heterocyclyl, R 3 is alkyl, aryl, cyclohexyl or heterocyclyl, or (C 1-4 )alkyl substituted by aryl, cyclohexyl or heterocyclyl, R 4 is H or alkyl, or R 3 and R 4 together with the carbon atom to which they are attached are cycloalkyl fused with aryl, and their use as pharmaceuticals.

  化合物的公式（I），其中R1是芳基，环己基或杂环基，或被芳基，环己基或杂环基取代的（C1-4）烷基，R2是定义的杂环基，R3是烷基，芳基，环己基或杂环基，或被芳基，环己基或杂环基取代的（C1-4）烷基，R4是H或烷基，或R3和R4与它们所连接的碳原子一起是环状烷基与芳基融合，以及它们作为药物的用途。
• AMIDE DERIVATIVES AND THEIR APPLICATION FOR THE TREAMENT OF G PROTEIN RELATED DISEASES
  申请人：NOVARTIS AG

  公开号：EP2001851A2

  公开（公告）日：2008-12-17
• [EN] QUARTERNARY PROFORMS OF TERTIARY AMINE CONTAINING COMPOUNDS<br/>[FR] PROFORMES QUATERNAIRES DE COMPOSES CONTENANT DES AMINES TERTIAIRES
  申请人：LEO PHARM PROD LTD

  公开号：WO2002042276A1

  公开（公告）日：2002-05-30

  The invention relates to a compound of general formula (I), wherein the moiety of formula (II), comprises one or more tertiary amines; R1 represents hydrogen, C1-4alkyl or aryl; A is an ester group (-O-C(O)-) or a carbonate group (-O-C(O)-O-); B represents poly-saccharide, poly-amino acid, poly-acrylate, poly-urea, poly-urethane, poly-vinyl pyrrolidone, poly-vinyl alcohol or -(CH2)m-[Y]n-(CH2)r-R, wherein R is C1-6alkyl, C3-6cycloalkyl, C2-6alkenyl, C2-6alkenyl, aryl, aralkyl, heteroaryl or non-aromatic hetorocyclic hydrocarbon, all of which are substituted with one or more substituents selected from the group consisting of amino, aminoalkyl, hydroxysulfonyloxy, dihydroxyphosphinoyl, dialkoxyphospinoyl, dihydroxyphosphinoyloxy, carboxy, sulfo, sulfamino, aminosulfonyl, aminocarbonyl, C1-4alkoxycarbonyl or aminoacylamino; R may also be (A), wherein q is an integer from 1 to 200, each R2 is independently hydrogen or methyl; and R3 is hydrogen or C1-4alkyl; Y is O or N(R4), wherein R4 is hydrogen or C1-4alkyl; m and r are independently an integer from 0 to 4; n is 0 or 1; Z is an anion such as chloride, bromide, iodide, sulphate, methanesulphate, p-toluenesulphonate or nitrate; and a salt thereof. The compounds are useful in increasing the solubility of compounds of formula (II).
• [EN] HETEROCYCLIC AMIDES FOR USE AS PHARMACEUTICALS<br/>[FR] AMIDES HETEROCYCLIQUES DESTINES A UNE UTILISATION EN TANT QUE PRODUITS PHARMACEUTIQUES
  申请人：NOVARTIS AG

  公开号：WO2007110237A2

  公开（公告）日：2007-10-04

  [EN] Compounds of Formula (I) wherein R₁ is aryl, cyclohexyl or heterocyclyl, or (C_1-4)alkyl substituted by aryl, cyclohexyl or heterocyclyl, R₂ is defined heterocyclyl, R₃ is alkyl, aryl, cyclohexyl or heterocyclyl, or (C_1-4)alkyl substituted by aryl, cyclohexyl or heterocyclyl, R₄ is H or alkyl, or R₃ and R₄ together with the carbon atom to which they are attached are cycloalkyl fused with aryl, and their use as pharmaceuticals.
  [FR] L'invention concerne des composés de formule (I), dans laquelle R₁ représente un aryle, un cyclohexyle ou un hétérocyclyle ou un (C_1-4)alkyle substitué par un aryle, un cyclohexyle ou un hétérocyclyle, R₂ représente un hétérocyclyle, R₃ représente un alkyle, un aryle, un cyclohexyle ou un hétérocyclyle ou un (C_1-4)alkyle substitué par un aryle, un cyclohexyle ou un hétérocyclyle, R₄ représente H ou un alkyle, ou bien R₃ et R₄ forment ensemble avec l'atome de carbone auquel ils sont attachés un cycloalkyle condensé avec un aryle. L'invention concerne également leur utilisation en tant que produits pharmaceutiques.