3Ufk9yxt92 | 1583277-38-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 3Ufk9yxt92
• 英文别名: (2S,3R,11bR)-3-(2-methylpropyl)-9-(trideuteriomethoxy)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine-2,10-diol
• CAS: 1583277-38-6；1977511-09-3
• 化学式: C18H27NO3
• 分子量: 308.4
• InChiKey: QPCCFQGYORNUSE-DWSRUFIWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  52.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• FORMULATIONS PHARMACOKINETICS OF DEUTERATED BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2
  申请人：Auspex Pharmaceuticals, Inc.

  公开号：US20140336386A1

  公开（公告）日：2014-11-13

  The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.
• FORMULATIONS AND PHARMACOKINETICS OF DEUTERATED BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2
  申请人：Auspex Pharmaceuticals, Inc.

  公开号：US20150004231A1

  公开（公告）日：2015-01-01

  The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.
• US20140341994A1
  申请人：——

  公开号：US20140341994A1

  公开（公告）日：2014-11-20
• FORMULATIONS and PHARMACOKINETICS OF DEUTERATED BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2
  申请人：Auspex Pharmaceuticals, Inc.

  公开号：US20160235733A1

  公开（公告）日：2016-08-18

  The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.
• US9233959B2
  申请人：——

  公开号：US9233959B2

  公开（公告）日：2016-01-12