N-[6-[bis(4-methoxyphenyl)-phenylmethoxy]hexyl]-2-(hydroxymethyl)-5-nitrobenzamide | 669073-05-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N-[6-[bis(4-methoxyphenyl)-phenylmethoxy]hexyl]-2-(hydroxymethyl)-5-nitrobenzamide
• CAS: 669073-05-6
• 化学式: C₃₅H₃₈N₂O₇
• 分子量: 598.696
• InChiKey: VGDUBLAXBAMQEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  44
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-[6-[bis(4-methoxyphenyl)-phenylmethoxy]hexyl]-2-(hydroxymethyl)-5-nitrobenzamide 在 吡啶 、 4-二甲氨基吡啶 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 、 乙酸乙酯 为溶剂， 反应 18.0h， 生成 Succinic acid 2-{6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyl}-4-nitro-benzyl ester 4-nitro-phenyl ester
  参考文献：
  名称：

  A novel solid support for the synthesis of 3 ′ -aminoalkylated oligonucleotides

  摘要：

  A novel improved controlled pore glass (CPG) support based on the 2-(hydroxymethyl)-6-nitrobenzoyl (HMNB) protecting group was developed for the synthesis of 3'-aminoalkylated oligonucleotides. The release of oligonucleotides with free 3'-amino groups from the support is complete within 2 h at 55 degreesC in concentrated ammonia. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.10.166
• 作为产物：
  描述：

  6-硝基苯酞 、 1-O-(4,4'-dimethoxytrityl)-6-amino-1-hexanol 在 三氯化铝 、 三乙胺 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 16.0h， 以8%的产率得到N-[6-[bis(4-methoxyphenyl)-phenylmethoxy]hexyl]-2-(hydroxymethyl)-5-nitrobenzamide
  参考文献：
  名称：

  A novel solid support for the synthesis of 3 ′ -aminoalkylated oligonucleotides

  摘要：

  A novel improved controlled pore glass (CPG) support based on the 2-(hydroxymethyl)-6-nitrobenzoyl (HMNB) protecting group was developed for the synthesis of 3'-aminoalkylated oligonucleotides. The release of oligonucleotides with free 3'-amino groups from the support is complete within 2 h at 55 degreesC in concentrated ammonia. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.10.166

文献信息

• Solid Support Reagents for Synthesis
  申请人：Hatala Paul J.

  公开号：US20100041866A1

  公开（公告）日：2010-02-18

  A compound which can be attached to a solid support and used as a reagent for methods of solid phase synthesis has the following structure: (I) where Ri is selected from hydrogen and C 1 -C 6 alkyl; R 2 is selected from hydrogen, hydroxy, and C 1 -C 6 alkoxy, or together R 1 and R 2 form a single bond; R 3 , R 4 , R 5 and R 6 are the same or different from each other and each represents hydrogen, C 1 -C 6 alkyl, and halogen, or together R 3 and R 4 with R 5 and R 6 form an aromatic ring, further wherein the aromatic ring is substituted with one or more X; X is selected from halogen, nitro, amino, and aminocarbonyl; s is 0, 1, 2, or 3, t is 0, 1, 2, or 3, wherein s+t≧1; R 7 and R 8 are the same or different from each other and each represents hydroxy, halogen, hydrogen, C 1 -C 6 alkoxy, oxyacyl, or together R 7 and R 8 form a carbonyl; Y is selected from a methylene or substituted methylene, nucleoside, nucleotide, protected nucleoside, protected nucleotide, C 1 -C 6 aryl, arylalkyl, heteroalkyl, heterocycle, and heteroaryl; n is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; Z is selected from OR and NHR; R is selected from hydrogen, SiR a , R b R c , CR a R b , R c , heteroalkyl, and C 1 -C 6 alkyl; R a , R b , and R c are the same as or different from each other and each represents methyl, ethyl, i-propyl, t-butyl, phenyl or substituted phenyl.
• US8362234B2
  申请人：——

  公开号：US8362234B2

  公开（公告）日：2013-01-29
• [EN] SOLID SUPPORT REAGENTS FOR SYNTHESIS<br/>[FR] RÉACTIFS À SUPPORTS SOLIDES POUR LA SYNTHÈSE
  申请人：ARCHEMIX CORP

  公开号：WO2007126941A2

  公开（公告）日：2007-11-08

  [EN] A compound which can be attached to a solid support and used as a reagent for methods of solid phase synthesis has the following structure: (I) where Ri is selected from hydrogen and C₁-C₆ alkyl; R₂ is selected from hydrogen, hydroxy, and C₁-C₆ alkoxy, or together R₁ and R₂ form a single bond; R₃, R₄, R₅ and R₆ are the same or different from each other and each represents hydrogen, C₁-C₆ alkyl, and halogen, or together R₃ and R₄ with R₅ and R₆ form an aromatic ring, further wherein the aromatic ring is substituted with one or more X; X is selected from halogen, nitro, amino, and aminocarbonyl; s is 0, 1, 2, or 3, t is 0, 1, 2, or 3, wherein s + t =1; R₇ and R₈ are the same or different from each other and each represents hydroxy, halogen, hydrogen, C₁-C₆ alkoxy, oxyacyl, or together R₇ and R₈ form a carbonyl; Y is selected from a methylene or substituted methylene, nucleoside, nucleotide, protected nucleoside, protected nucleotide, C₁-C₆ aryl, arylalkyl, heteroalkyl, heterocycle, and heteroaryl; n is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; Z is selected from OR and NHR; R is selected from hydrogen, SiR^a,R^bR^c, CR^aR^b, R^c, heteroalkyl, and C₁-C₆ alkyl; R^a, R^b, and R^c are the same as or different from each other and each represents methyl, ethyl, i-propyl, t-butyl, phenyl or substituted phenyl.
  [FR] La présente invention concerne un composé pouvant se lier à un support solide et utilisé comme réactif pour des procédés de synthèse en phase solide de formule (I), dans laquelle: R1 est choisi parmi l'hydrogène, et alkyle C₁-C₆; R₂est choisi parmi l'hydrogène, hydroxy, et alcoxy C₁-C₆, ou R₁ et R₂ ensemble forment une liaison simple; R₃, R₄, R₅ et R₆, identiques ou différents, représentent chacun l'hydrogène, alkyle C₁-C₆, et halogène, ou R₃ et R₄ ensemble avec R₅ et R₆ forment un noyau aromatique, ledit noyau aromatique étant en outre substitué avec un ou des X; X est choisi parmi halogène, nitro, amino, et aminocarbonyle; s est 0, 1, 2, ou 3; t est 0, 1, 2, ou 3, où s + t = 1; R₇ et R₈, identiques ou différents, représentent chacun hydroxy, halogène, hydrogène, alcoxy C₁-C₆, oxyacyle, ou R₇ et R₈ ensemble forment un carbonyle; Y est choisi parmi méthylène ou méthylène substitué, nucléoside, nucléotide, nucléoside protégé, nucléotide protégé, aryle C₅-C₈, aralalkyle, hétéroalkyle, hétérocycle, et hétéroaryle; n est 1, 2, 3, 4, 5, 6, 7, 8, 9, ou 10; Z est choisi parmi OR et NHR. R est choisi parmi hydrogène, SiR^a,R^bR^c, CR^aR^b, R^c, hétéroalkyle, R^a, R^b, et R^c, identiques ou différents, représentent chacun méthyle, éthyle, i-propyle, t-butyle, phényle ou phényle substitué.