4-fluoro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid | 1190314-95-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 4-fluoro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid
• CAS: 1190314-95-4
• 化学式: C₈H₅FN₂O₂
• 分子量: 180.14
• InChiKey: DKZKIAYGAZBOSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Heterocyclic N-Oxides as Hypoxic Selective Protein Kinase Inhibitors
  申请人：Boyle Robert George

  公开号：US20100048540A1

  公开（公告）日：2010-02-25

  The invention relates to novel heterocyclic N-oxides which are useful as hypoxic selective cytotoxic agents that mediate and/or inhibit cell proliferation, for example, through the activity of protein kinases. The invention is further related to pharmaceutical compositions containing such compounds and compositions, and to methods of treating cancer as well as other disease states associated with unwanted ahgiogenesis and/or cellular proliferation by administering effective amounts of such compounds.