N-Methyl-N-[4-[(1-naphthalenyl)thio]butyl]benzeneethanamine oxalate | 152858-95-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-Methyl-N-[4-[(1-naphthalenyl)thio]butyl]benzeneethanamine oxalate
• 英文别名: N-methyl-4-naphthalen-1-ylsulfanyl-N-(2-phenylethyl)butan-1-amine;oxalic acid
• CAS: 152858-95-2
• 化学式: C₂H₂O₄*C₂₃H₂₇NS
• 分子量: 439.576
• InChiKey: ZCPRXOHSMPQIDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.04
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Central nervous system antiischemic agents
  申请人：Bristol-Myers Squibb Company

  公开号：EP0559569A1

  公开（公告）日：1993-09-08

  A series of phenylalkylaminoalkyl derivatives of Formula I wherein Ar is naphtyl or phenyl;    R¹ is hydrogen, fluoro or R⁴CONH-;    R² is hydrogen or C₁-₆ alkyl;    R₃ is C₁-₆ alkyl;    R⁴ is C₁-₆ alkyl or phenyl- C₁-₆ alkyl;    x is zero or the integers 1 and 2;    m is selected from the integers 1 to 6; and    n is selected from the integers 2 and 3, has been found to provide effective antiischemic protection for CNS tissue, particularly neurons. A method of treatment to protect against CNS ischemia, such as that resulting from trauma or stroke or other ischemic conditions, comprises administration of these novel compounds to an individual in need of such treatment.

  一系列的Formula I的苯基烷基氨基烷基衍生物已被发现能够为中枢神经系统组织，特别是神经元，提供有效的抗缺血保护。一种治疗方法用于保护中枢神经系统缺血，例如由创伤、中风或其他缺血病症引起的缺血情况，包括将这些新化合物用于需要此类治疗的个体。其中Ar为萘基或苯基；R¹为氢、氟或R⁴CONH-；R²为氢或C₁-₆烷基；R₃为C₁-₆烷基；R⁴为C₁-₆烷基或苯基-C₁-₆烷基；x为零或整数1和2；m从整数1到6中选择；n从整数2和3中选择。