(1R,2S,5S)-7-Benzyl-2-(3-carboxy-propyl)-3,7-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester | 771478-79-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (1R,2S,5S)-7-Benzyl-2-(3-carboxy-propyl)-3,7-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester
• CAS: 771478-79-6
• 化学式: C₂₃H₃₄N₂O₄
• 分子量: 402.534
• InChiKey: SGYJVDHSRFMWHD-ZCNNSNEGSA-N

反应信息

• 作为反应物：
  描述：

  (1R,2S,5S)-7-Benzyl-2-(3-carboxy-propyl)-3,7-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 36.0h， 生成 (1R,5R,11aS)-8-Oxo-octahydro-1,5-methano-pyrido[1,2-a][1,5]diazocine-3-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Access to novel substituted diazaadamantanes via semi-natural tetrahydrocytisine

  摘要：

  Novel 1,3-diazaadamantane structures 3 and 6 were prepared from tetrahyd to (-)-cytisine 1 using intermolecular conversions within the bispidine moiety. 2-Oxo derivative 6 was synthesized using a microwave-assisted procedure, which reduces the reaction time and increases the purity of the crude reaction mixture. Alternative possibilities of intermolecular cyclizations were also explored. Though less successful, they provided interesting insights into the chemistry of bispidine systems. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.07.056
• 作为产物：
  描述：

  (1R,2S,5S)-7-Benzyl-2-(3-methoxycarbonyl-propyl)-3,7-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester 在 sodium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以88%的产率得到(1R,2S,5S)-7-Benzyl-2-(3-carboxy-propyl)-3,7-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Access to novel substituted diazaadamantanes via semi-natural tetrahydrocytisine

  摘要：

  Novel 1,3-diazaadamantane structures 3 and 6 were prepared from tetrahyd to (-)-cytisine 1 using intermolecular conversions within the bispidine moiety. 2-Oxo derivative 6 was synthesized using a microwave-assisted procedure, which reduces the reaction time and increases the purity of the crude reaction mixture. Alternative possibilities of intermolecular cyclizations were also explored. Though less successful, they provided interesting insights into the chemistry of bispidine systems. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.07.056