(4R)-2-[(4-Bromophenyl)methyl]-4-hydroxy-L-proline | 634615-76-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (4R)-2-[(4-Bromophenyl)methyl]-4-hydroxy-L-proline
• 英文别名: (2S,4R)-2-[(4-bromophenyl)methyl]-4-hydroxypyrrolidine-2-carboxylic acid
• CAS: 634615-76-2
• 化学式: C₁₂H₁₄BrNO₃
• 分子量: 300.15
• InChiKey: VMYWEQFJZCICDA-PWSUYJOCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Spiro-cyclic compounds useful as anti-inflammatory agents
  申请人：Dhar Murali T. G.

  公开号：US20050119279A1

  公开（公告）日：2005-06-02

  The present invention is directed to compounds having the formula (I): useful in treating inflammatory and immune diseases, in which K and L are independently, O or S; Q is —C(═O)— or optionally substituted C 1-6 alkylene; Ar is optionally-substituted aryl or heteroaryl; J 1 , J 2 , J 3 and Y are selected so that ring A is a five-to-six membered optionally-substituted cycloalkenyl or heterocyclo ring having 0 to 2 nitrogen heteroatoms; R 1 is N or C(R 9 ); and R 2 , and R 3 , are as defined in the specification.

  本发明涉及具有以下结构式（I）的化合物：用于治疗炎症和免疫性疾病，在其中K和L分别是O或S；Q是—C(═O)—或可选择取代的C1-6烷基；Ar是可选择取代的芳基或杂环芳基；J1、J2、J3和Y被选择为使环A成为一个含有0到2个氮杂原子的五元至六元可选择取代的环烯烃基或杂环烷基；R1是N或C(R9)；而R2和R3如规范中所定义。
• US7199125B2
  申请人：——

  公开号：US7199125B2

  公开（公告）日：2007-04-03