1-[(4-Methoxyphenyl)methyl]piperidine-3-carbaldehyde | 716339-55-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-[(4-Methoxyphenyl)methyl]piperidine-3-carbaldehyde
• CAS: 716339-55-8
• 化学式: C₁₄H₁₉NO₂
• 分子量: 233.31
• InChiKey: SZRWEBHIZDPBIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  {1-[(4-Methoxyphenyl)methyl]piperidin-3-yl}methanol 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 1-[(4-Methoxyphenyl)methyl]piperidine-3-carbaldehyde
  参考文献：
  名称：

  Piperidine derivatives useful as CCR5 antagonists

  摘要：

  本发明提供了以下式的化合物1或其药学上可接受的盐或溶剂，其中各种基团如规范中所定义。本发明还提供了含有本发明化合物的药物组合物，以及使用本发明化合物的治疗方法。该发明还涉及使用本发明化合物与一种或多种抗病毒或其他对治疗人类免疫缺陷病毒（HIV）有用的药剂的组合。该发明进一步涉及使用本发明化合物，单独或与另一药剂结合，治疗固体器官移植排斥、移植物抗宿主病、关节炎、类风湿关节炎、炎症性肠病、特应性皮炎、牛皮癣、哮喘、过敏或多发性硬化症。

  公开号：

  US20040132711A1

文献信息

• [EN] PIPERIDINE ISOXAZOLE AND ISOTHIAZOLE OREXIN RECEPTOR ANTAGONISTS<br/>[FR] COMPOSÉS PIPÉRIDINES ISOXAZOLES ET ISOTHIAZOLES ANTAGONISTES DES RÉCEPTEURS DE L'OREXINE
  申请人：MERCK SHARP & DOHME

  公开号：WO2016065585A1

  公开（公告）日：2016-05-06

  The present invention is directed to piperidine isoxazole and isothiazole orexin compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及对脑嗜睡肽受体的拮抗剂——哌啶异噁唑和异噻唑化合物。本发明还涉及所述化合物在潜在的治疗或预防涉及脑嗜睡肽受体的神经和精神障碍和疾病中的用途。本发明还涉及包含这些化合物的组合物。本发明还涉及这些组合物在预防或治疗涉及脑嗜睡肽受体的疾病中的用途。
• PIPERIDINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS
  申请人：Miller W. Michael

  公开号：US20080095740A1

  公开（公告）日：2008-04-24

  The present invention provides a compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein the various moieties are as defined in the specification. The present invention also provides pharmaceutical compositions containing the compound of this invention, and methods of treatment using the compound of this invention. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.
• US7307081B2
  申请人：——

  公开号：US7307081B2

  公开（公告）日：2007-12-11
• Piperidine derivatives useful as CCR5 antagonists
  申请人：Schering Corporation

  公开号：US20040132711A1

  公开（公告）日：2004-07-08

  The present invention provides a compound of the formula 1 or a pharmaceutically acceptable salt or solvate thereof, wherein the various moieties are as defined in the specification. The present invention also provides pharmaceutical compositions containing the compound of this invention, and methods of treatment using the compound of this invention. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.

  本发明提供了以下式的化合物1或其药学上可接受的盐或溶剂，其中各种基团如规范中所定义。本发明还提供了含有本发明化合物的药物组合物，以及使用本发明化合物的治疗方法。该发明还涉及使用本发明化合物与一种或多种抗病毒或其他对治疗人类免疫缺陷病毒（HIV）有用的药剂的组合。该发明进一步涉及使用本发明化合物，单独或与另一药剂结合，治疗固体器官移植排斥、移植物抗宿主病、关节炎、类风湿关节炎、炎症性肠病、特应性皮炎、牛皮癣、哮喘、过敏或多发性硬化症。