5-fluoro-2-({(3R,6R)-6-methyl-1-[2-(2-phenylethyl)benzoyl]piperidin-3-yl}methoxy)pyridine | 1088992-02-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 5-fluoro-2-({(3R,6R)-6-methyl-1-[2-(2-phenylethyl)benzoyl]piperidin-3-yl}methoxy)pyridine
• 英文别名: [(2R,5R)-5-[(5-fluoropyridin-2-yl)oxymethyl]-2-methylpiperidin-1-yl]-[2-(2-phenylethyl)phenyl]methanone
• CAS: 1088992-02-2
• 化学式: C₂₇H₂₉FN₂O₂
• 分子量: 432.538
• InChiKey: CEUWCOPGMSWESG-IFMALSPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• PYRIDYL PIPERIDINE OREXIN RECEPTOR ANTAGONISTS
  申请人：Breslin Michael J.

  公开号：US20100168134A1

  公开（公告）日：2010-07-01

  The present invention is. directed to pyridyl piperidine compounds of formula (I) which are antagonists of orexin receptors, and which are useful' in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及式(I)的吡啶基哌啶化合物，其为促进睡眠激素受体的拮抗剂，可用于治疗或预防神经和精神障碍以及涉及促进睡眠激素受体的疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及促进睡眠激素受体的疾病中的用途。
• US8242121B2
  申请人：——

  公开号：US8242121B2

  公开（公告）日：2012-08-14
• US8569311B2
  申请人：——

  公开号：US8569311B2

  公开（公告）日：2013-10-29
• [EN] PYRIDYL PIPERIDINE OREXIN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DE RÉCEPTEUR D'OREXINE PIPÉRIDYL PIPÉRIDINE
  申请人：MERCK & CO INC

  公开号：WO2008147518A1

  公开（公告）日：2008-12-04

  [EN] The present invention is. directed to pyridyl piperidine compounds of formula (I) which are antagonists of orexin receptors, and which are useful' in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
  [FR] La présente invention concerne des composés pyridyl pipéridine de formule (I) qui sont des antagonistes de récepteur d'orexine, et qui sont utiles dans le traitement ou la prévention de troubles et maladies neurologiques et psychiatriques dans lesquels les récepteurs d'orexine sont impliqués. L'invention concerne des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et compositions dans la prévention et le traitement de telles maladies dans lesquelles des récepteurs d'orexine sont impliqués.