N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]naphthalene-2-carboxamide | 850467-67-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]naphthalene-2-carboxamide
• CAS: 850467-67-3
• 化学式: C₂₃H₂₂N₂O₂
• 分子量: 358.4
• InChiKey: UBIKJGRVXIINFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Tao Kinase Modulators And Method Of Use
  申请人：Baly Lynn Deborah

  公开号：US20070208166A1

  公开（公告）日：2007-09-06

  The invention provides compounds and methods for inhibition of kinases, such as those of the TAO family, more specifically KIAA1361, TAO, and JIK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

  该发明提供了用于抑制激酶的化合物和方法，例如TAO家族的激酶，更具体地是KIAA1361、TAO和JIK激酶。该发明提供了用于调节蛋白激酶酶活性以调节细胞活动（如增殖、分化、程序性细胞死亡、迁移和趋化入侵）的化合物。该发明的化合物抑制、调节和/或调节与细胞活动变化相关的激酶受体信号转导途径，并且该发明包括含有这些化合物的组合物，并且使用它们来治疗依赖激酶的疾病和状况的方法。