摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

N'-(Tetrahydropyran-4-carbonyl)-N-methylpiperazin | 10001-14-6

中文名称
——
中文别名
——
英文名称
N'-(Tetrahydropyran-4-carbonyl)-N-methylpiperazin
英文别名
(4-Methyl-1-piperazinyl)(tetrahydro-2H-pyran-4-yl)methanone;(4-methylpiperazin-1-yl)-(oxan-4-yl)methanone
N'-(Tetrahydropyran-4-carbonyl)-N-methylpiperazin化学式
CAS
10001-14-6
化学式
C11H20N2O2
mdl
MFCD21366980
分子量
212.292
InChiKey
QCEHJJNPSIBBGF-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    -0.2
  • 重原子数:
    15
  • 可旋转键数:
    1
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.909
  • 拓扑面积:
    32.8
  • 氢给体数:
    0
  • 氢受体数:
    3

文献信息

  • CHEMICAL COMPOUNDS-821
    申请人:Finlay Maurice Raymond
    公开号:US20090048269A1
    公开(公告)日:2009-02-19
    The invention relates to chemical compounds of the formula (I), or pharmaceutically acceptable salts thereof, which possess ALK5 (TGFβR1) inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an anti-cancer effect in a warm-blooded animal such as man.
    该发明涉及化学式(I)的化合物,或其药学上可接受的盐,具有ALK5(TGFβR1)抑制活性,因此在抗癌活性方面有用,从而在治疗人体或动物体的方法中有用。该发明还涉及制造上述化学化合物的方法,含有它们的药物组合物,以及它们在制造用于在温血动物(如人)中产生抗癌效果的药物中的使用。
  • [EN] SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS<br/>[FR] COMPOSÉS SUBSTITUÉS DE PYRAZOLO[1,5-A]PYRIDINES COMME INHIBITEURS DE LA KINASE RET
    申请人:ARRAY BIOPHARMA INC
    公开号:WO2017011776A1
    公开(公告)日:2017-01-19
    Provided herein are compounds of the General Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.
    本文提供了一般式I的化合物及其立体异构体和药用可接受的盐或溶剂,其中A、B、D、E、X1、X2、X3和X4的含义如规范中所述,这些化合物是RET激酶的抑制剂,可用于治疗和预防可以用RET激酶抑制剂治疗的疾病,包括由RET激酶介导的疾病或紊乱。
  • RAC INHIBITORS
    申请人:Geneyus LLC
    公开号:US20190031647A1
    公开(公告)日:2019-01-31
    The present invention relates to compounds that act as pan-Rac inhibitors, compositions including the compounds, and methods of using the compounds. In particular, the compounds are useful for treating certain cancers such as breast cancer.
    本发明涉及作为泛Rac抑制剂的化合物,包括该化合物的组合物,以及使用该化合物的方法。具体来说,这些化合物可用于治疗特定癌症,如乳腺癌。
  • Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
    申请人:Array BioPharma, Inc.
    公开号:US10174028B2
    公开(公告)日:2019-01-08
    Provided herein are compounds of the General Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.
    本文提供的是通式 I 的化合物: 及其立体异构体和药学上可接受的盐或溶液,其中 A、B、D、E、X1、X2、X3 和 X4 具有说明书中给出的含义,它们是 RET 激酶的抑制剂,可用于治疗和预防可以用 RET 激酶抑制剂治疗的疾病,包括由 RET 激酶介导的疾病或紊乱。
  • Rac inhibitors
    申请人:Geneyus LLC
    公开号:US10472352B2
    公开(公告)日:2019-11-12
    The present invention relates to compounds that act as pan-Rac inhibitors, compositions including the compounds, and methods of using the compounds. In particular, the compounds are useful for treating certain cancers such as breast cancer.
    本发明涉及作为泛 Rac 抑制剂的化合物、包括这些化合物的组合物以及使用这些化合物的方法。特别是,这些化合物可用于治疗某些癌症,如乳腺癌。
查看更多