| 1241-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• CAS: 1241-92-5
• 化学式: C₁₈H₂₈N₅O₂*Cl
• 分子量: 381.906
• InChiKey: MELGZSUMAODQQB-UHFFFAOYSA-M

反应信息

• 作为产物：
  描述：

  三乙烯二胺 、 对硝基氯苯 以 乙腈 为溶剂， 反应 0.5h， 以7%的产率得到
  参考文献：
  名称：

  Efficient microwave-assisted three-component one-pot preparation of 1-aryl-4-(2-acetoxyethyl)piperazines and 1-aryl-4-(2-acetoxyethyl)piperidines

  摘要：

  A highly efficient one-pot, three-component microwave-assisted procedure has been developed for the preparation of 1-(para-substituted-aryl)-4-(2-acetoxyethyl)piperazines and 1-(para-substituted-aryl)-4(2-acetoxyethyl)piperidines. Microwave-accelerated heating of electron-deficient aryl halides and potassium acetate with either 1,4-diazabicyclo[2.2.2]octane (DABCO) or quinuclidine at 180 degrees C for 120 min provided the title products in good yields and with general substrate scope. Similarly, subjection of potassium pthalimide instead of potassium acetate to the same conditions provided good yields of 1-arylpiperazines and 1-arylpiperidines containing a 2-phthalimidoethyl substituent at the C-4 position. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.04.027