TCH-013a | 1132091-17-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: TCH-013a
• 英文别名: TCH-018；(4R,5R)-ethyl 1-benzyl-4,5-dihydro-2,4,5-triphenyl-1H-imidazole-4-carboxylate；(4R*,5R*)-1-Benzyl-2,4,5-triphenyl-4,5-dihydro-1H-imidazole-4-carboxylic acid ethyl ester；ethyl (4R,5R)-3-benzyl-2,4,5-triphenyl-4H-imidazole-5-carboxylate
• CAS: 1132091-17-8
• 化学式: C₃₁H₂₈N₂O₂
• 分子量: 460.576
• InChiKey: PVUSNWSCRYFKFI-GRKNLSHJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Substituted Imidazoline Compounds
  申请人：Tepe Jetze

  公开号：US20090156830A1

  公开（公告）日：2009-06-18

  The invention relates to compositions comprising substituted imidazoline compounds including prodrugs, and salts thereof. In some embodiments, the invention relates to the use of these compositions as therapeutic agents, preferably for the treatment of arthritis or cancer. In further embodiments, The invention relates to the pharmaceutical compositions with effective amounts of substituted imidazoline compounds disclosed herein that function as agonist or antagonists of the genetic expression or interactions with transcription factor NF-κB.
• TREATMENT OF MALIGNANCIES
  申请人：Board of Trustees of Michigan State University

  公开号：US20190030002A1

  公开（公告）日：2019-01-31

  Compositions and methods are described herein that include imidazole compounds that are useful for treatment of certain cancers, particularly metastatic cancers such as of glioblastomas, osteosarcomas, histiocytic sarcomas, mastocytomas, and sarcomas.
• US8252942B2
  申请人：——

  公开号：US8252942B2

  公开（公告）日：2012-08-28