N2-(3-chloro-4-methoxy-5-methylphenyl)-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-2,4-pyrimidinediamine | 662227-22-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: N2-(3-chloro-4-methoxy-5-methylphenyl)-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-2,4-pyrimidinediamine
• 英文别名: 2-N-(3-chloro-4-methoxy-5-methylphenyl)-4-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-fluoropyrimidine-2,4-diamine
• CAS: 662227-22-7
• 化学式: C₂₀H₁₈ClFN₄O₃
• 分子量: 416.839
• InChiKey: SNAIRQQSNZJNFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  77.5
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP2130541A2

  公开（公告）日：2009-12-09

  The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

  本发明提供了用2,4-嘧啶二胺化合物治疗或预防自身免疫性疾病的方法，以及治疗、预防或改善与此类疾病相关的症状的方法。可使用本发明化合物治疗或预防的自身免疫性疾病的具体实例包括类风湿性关节炎和/或其相关症状、系统性红斑狼疮和/或其相关症状以及多发性硬化症和/或其相关症状。
• Methods of Treating or Preventing Autoimmune Diseases With 2,4-Pyrimidinediamine Compounds
  申请人：Singh Rajinder

  公开号：US20120230984A1

  公开（公告）日：2012-09-13

  The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.
• US7517886B2
  申请人：——

  公开号：US7517886B2

  公开（公告）日：2009-04-14
• US7812029B1
  申请人：——

  公开号：US7812029B1

  公开（公告）日：2010-10-12
• US7825116B2
  申请人：——

  公开号：US7825116B2

  公开（公告）日：2010-11-02