| 1272665-02-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• CAS: 1272665-02-7
• 化学式: C₁₉H₄₂O₂Si
• 分子量: 330.627
• InChiKey: FOQMEYHRXCLRFV-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.15
• 重原子数：
  22.0
• 可旋转键数：
  13.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.46
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  在 正丁基锂 、 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 tert-butyl-dimethyl-[(11S)-11-methyltridec-12-enoxy]silane
  参考文献：
  名称：

  Xestoproxamines A−C from Neopetrosia proxima. Assignment of Absolute Stereostructure of Bis-piperidine Alkaloids by Integrated Degradation-CD Analysis

  摘要：

  The complete stereostructures of xestoproxamines A-C, from the Bahamian sponge Neopetrosia proxima, were assigned from spectroscopic analysis, including MS, 2D NMR, and integrated degradation-CD analysis. Two new CD application protocols are described for defining absolute configuration: one for allylic methyl groups in branched chains and a second for the heterocyclic core bis-piperidine with Specific applicability to other members of this class alkaloids-known for their stereoheterogeneity-and tertiary cyclic amines in general.

  DOI：

  10.1021/np1008637
• 作为产物：
  描述：

  在 四氢吡咯 、 正丁基锂 、 硼烷四氢呋喃络合物 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以41%的产率得到
  参考文献：
  名称：

  Xestoproxamines A−C from Neopetrosia proxima. Assignment of Absolute Stereostructure of Bis-piperidine Alkaloids by Integrated Degradation-CD Analysis

  摘要：

  The complete stereostructures of xestoproxamines A-C, from the Bahamian sponge Neopetrosia proxima, were assigned from spectroscopic analysis, including MS, 2D NMR, and integrated degradation-CD analysis. Two new CD application protocols are described for defining absolute configuration: one for allylic methyl groups in branched chains and a second for the heterocyclic core bis-piperidine with Specific applicability to other members of this class alkaloids-known for their stereoheterogeneity-and tertiary cyclic amines in general.

  DOI：

  10.1021/np1008637

文献信息

• Liposomal Circular Dichroism (L-CD) of Arenoyl Derivatives of Sphingolipids. Amplification of Cotton Effects in Ordered Lipid Bilayers
  作者：Tadeusz Molinski、Caroline Broaddus、Brandon Morinaka

  DOI：10.3390/md15120352

  日期：——

  Liposomal circular dichroism (L-CD) of acyclic amino alcohols exhibit amplification of Cotton effects when measured in highly uniform, unilamellar liposomes. The effect is likely due to intermolecular associations-H-aggregates-that self-assemble spontaneously within the lipid bilayer, and persists over long time scales. L-CD spectra of N,O,O'-tri-(6'methoxy-2'-naphthoyl)-d-erythro-sphingosine, or the

  当在高度均匀的单层脂质体中测量时，无环氨基醇的脂质体圆二色性（L-CD）表现出棉花效应的放大。这种效应可能是由于分子间缔合——H-聚集体——在脂质双层内自发地自组装，并持续很长一段时间。N,O,O'-三-(6'甲氧基-2'-萘甲酰基)-d-赤型-鞘氨醇或相应的二氢衍生物（二氢鞘氨醇）的 L-CD 光谱显示，棉花对各向同性溶液中记录的传统 CD 光谱的影响。