Naforidaifen E | 1133396-70-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: Naforidaifen E
• 英文别名: 4-[4-(2-diethylamino-1-yl-ethoxy)phenyl]-7-(2-diethylamino-1-yl-ethoxy)-3-phenyl-1,2-dihydronaphthalene；2-[4-[6-[2-(diethylamino)ethoxy]-2-phenyl-3,4-dihydronaphthalen-1-yl]phenoxy]-N,N-diethylethanamine
• CAS: 1133396-70-9
• 化学式: C₃₄H₄₄N₂O₂
• 分子量: 512.736
• InChiKey: WHDKLJVEBSYEOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  38
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  24.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• NOVEL DIHYDRONAPHTHALENE COMPOUND AND USE THEREOF
  申请人：Shiina Isamu

  公开号：US20100249400A1

  公开（公告）日：2010-09-30

  Disclosed is a compound represented by the formula (I) below as a dihydronaphthalene compound having a chemical structure which is excellent in production efficiency when compared with lasofoxifene and nafoxidine. This compound is useful as a proteasome inhibitor and/or an antitumor agent. (In the formula, two —(CH 2 ) l —N(R 1 ) (R 2 ) groups represent a same substituent; R 1 and R 2 each represents a hydrogen atom, or a same or different alkyl group; or alternatively, R 1 and R 2 may combine together to form a monocyclic heterocyclic ring with a nitrogen atom having them or additionally together with one or more atoms selected from an oxygen atom, a sulfur atom and a nitrogen atom; R 3 , R 4 and R 5 each represents one or more substituents selected from a hydrogen atom, an alkyl group, an acyl group, an alicyclic group, an aromatic group, a halogen atom, an acyloxy group, a cyano group and a nitro group; l represents an integer of 2-5; n represents an integer of 1-4; m represents an integer of 1-5; and q represents an integer of 1-3.)

  本发明涉及一种化合物，其化学结构为二氢萘类化合物，由公式（I）表示，与拉索福辛和纳福西丁相比，其生产效率更高。该化合物可用作蛋白酶体抑制剂和/或抗肿瘤剂。（在公式中，两个—（CH2）l—N（R1）（R2）基团表示相同的取代基；R1和R2分别表示氢原子或相同或不同的烷基基团；或者，R1和R2可以结合在一起形成一个单环杂环，其中含有氮原子或与氮原子一起选择的一个或多个原子，如氧原子、硫原子和氮原子；R3、R4和R5分别表示从氢原子、烷基基团、酰基基团、脂环基团、芳基基团、卤素原子、酰氧基团、氰基团和硝基团中选择的一个或多个取代基；l表示2-5的整数；n表示1-4的整数；m表示1-5的整数；q表示1-3的整数。）
• Novel dihydronaphthalene compound and use thereof
  申请人：Tokyo University Of Science Educational Foundation Administrative Organization

  公开号：EP2192108B1

  公开（公告）日：2013-03-27
• US8183235B2
  申请人：——

  公开号：US8183235B2

  公开（公告）日：2012-05-22