3-methyl-3-pentyl-3H-diazirine | 14359-93-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环化合物
• 英文名称: 3-methyl-3-pentyl-3H-diazirine
• 英文别名: 3-Methyl-3-pentyldiazirine
• CAS: 14359-93-4
• 化学式: C₇H₁₄N₂
• 分子量: 126.202
• InChiKey: FDYIRKJJXRNTIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] ANTI-EGFR ANTIBODY DRUG CONJUGATE<br/>[FR] CONJUGUÉ MÉDICAMENT-ANTICORPS ANTI-EGFR
  申请人：MEDITOPE BIOSCIENCES INC

  公开号：WO2017136581A1

  公开（公告）日：2017-08-10

  The present disclosure is directed to meditope-antibody covalent binding modalities that can be activated only after the meditope associates with a binding site on the meditope-enabled antibody. To this end, provided herein is a meditope engineered to contain a photoreactive functional group at one or more specific location(s) on the meditope so as not interfere with the specific noncovalent molecular interaction with the binding site on the meditope-enabled antibody, but still permits, and enhances, covalent bond formation. This methodology, with its speed, accuracy, consistency and simplicity has evident advantages for the development of antibody-drug conjugates.