(E)-4-(2-fluorostyryl)-N,N-dimethylnaphthalen-1-amine | 1266683-96-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-4-(2-fluorostyryl)-N,N-dimethylnaphthalen-1-amine
• 英文别名: 4-[(E)-2-(2-fluorophenyl)ethenyl]-N,N-dimethylnaphthalen-1-amine
• CAS: 1266683-96-8
• 化学式: C₂₀H₁₈FN
• 分子量: 291.368
• InChiKey: FCSGHGQOIVNPIM-VAWYXSNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• STILBENE ANALOGS AND METHODS OF TREATING CANCER
  申请人：WATT David

  公开号：US20120196874A1

  公开（公告）日：2012-08-02

  Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. The halogenated stilbene analogs include nitrogen heteroaryl groups and/or amino groups on the stilbene ring.

  本发明揭示了对于治疗各种癌症，包括但不限于结肠直肠癌（CRC）和乳腺癌有用的Stilbene类似物和制药组合物。卤代Stilbene类似物包括氮杂环基团和/或氨基团在Stilbene环上。
• Method of treating a methionine-dependent cancer
  申请人：Agency for Science, Technology and Research

  公开号：US11376256B2

  公开（公告）日：2022-07-05

  The present specification relates generally to a therapeutic protocol for treating a subject having cancer. Taught herein is a method of treating cancer or reducing the risk of recurrence of cancer in a subject following an anti-cancer therapy.

  本说明书一般涉及一种用于治疗癌症患者的治疗方案。这里教给大家的是一种治疗癌症或降低抗癌治疗后癌症复发风险的方法。
• MAT2A INHIBITORS FOR TREATING MTAP NULL CANCER
  申请人：Agios Pharmaceuticals, Inc.

  公开号：US20180371551A1

  公开（公告）日：2018-12-27

  The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with a MAT2A inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by a MAT2A inhibitor, comprising assessing whether the tumor cell is absent an MTAP gene whereby cells that are MTAP null are sensitive to inhibition by MAT2A inhibitors.
• US8664276B2
  申请人：——

  公开号：US8664276B2

  公开（公告）日：2014-03-04
• US9132102B2
  申请人：——

  公开号：US9132102B2

  公开（公告）日：2015-09-15