1-((3-methoxyphenyl)(piperidin-1-yl)methyl)naphthalen-2-ol | 1393729-31-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-((3-methoxyphenyl)(piperidin-1-yl)methyl)naphthalen-2-ol
• CAS: 1393729-31-1
• 化学式: C₂₃H₂₅NO₂
• 分子量: 347.457
• InChiKey: DGMGPDNBKDDGHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.13
• 重原子数：
  26.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  32.7
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  哌啶 、 3-甲氧基苯甲醛 、 2-萘酚 在 nano-Fe₃O₄(at)carbon quantum dots(at)Si(OEt)(CH₂)3NH(at)cyanuric acid(at)N₃(at)phenylacetylene(at)copper catalyst 作用下， 以 neat (no solvent) 为溶剂， 反应 0.13h， 以70%的产率得到1-((3-methoxyphenyl)(piperidin-1-yl)methyl)naphthalen-2-ol
  参考文献：
  名称：

  使用工程化铜基纳米磁性催化剂合成 1-氨基烷基-2-萘酚衍生物（Fe3O4@CQD@Si (OEt)(CH2)3NH@CC@N3@苯基乙炔@Cu）

  摘要：

  在本研究中，基于分子水平的工程化方法用于合成铜基纳米磁性催化剂（Fe 3 O 4 @CQD@Si (OEt)(CH 2 ) 3 NH@CC@N 3 @苯基乙炔@Cu） . 使用不同的技术对合成的催化剂进行表征，包括红外（IR）、X 射线粉末衍射（XRD）、场发射扫描电子显微镜（FESEM）和透射电子显微镜（TEM）、能量色散 X 射线光谱（ EDX) 和 EDX 元素映射、感应耦合等离子体 (ICP)、热重分析 (TGA) 和差热分析 (DTA) 以及振动样品磁强计 (VSM)。Fe 3 O 4使用碳量子点 (CQD) 代替传统的 SiO 2保护纳米粒子表面. 在 1-氨基烷基-2-萘酚衍生物的合成中评估了所合成催化剂的活性。反应时间短、反应收率高的无溶剂条件是所制备催化剂的结果。反应如何被催化剂触发由 IR 确定。合成后的催化剂在五个循环后提供了 87.5% 的反应产率。采用傅里叶变换红外

  DOI：

  10.1002/aoc.6361

文献信息

• Supported copper triflate as an efficient catalytic system for the synthesis of highly functionalized 2-naphthol Mannich bases under solvent free condition
  作者：Someshwar D. Dindulkar、Vedavati G. Puranik、Yeon Tae Jeong

  DOI：10.1016/j.tetlet.2012.06.022

  日期：2012.8

  Various heterogeneous catalysts (Lewis acid) have been prepared and screened for the synthesis of Betti bases in an attempt to reduce the environmental hazards associated with the conventional homogeneous Lewis acid system. And we found especially Cu(OTf)(2)center dot SiO2 catalyzes the three-component coupling of aldehyde, 2-naphthol, and alicyclic amine to generate Betti base with high efficiency under neat conditions without additional co-catalyst or additive in air. The reaction is not sensitive to water and occurs smoothly in water as well. (c) 2012 Elsevier Ltd. All rights reserved.
• Magnetic nanocrystallites strontium hexaferrite as an efficient catalyst in the green Betti reaction
  作者：Ghodsi Mohammadi Ziarani、Zhila Kazemi Asl、Parisa Gholamzadeh、Alireza Badiei、Morteza Afshar

  DOI：10.1080/24701556.2019.1574816

  日期：2018.10.3

  The sol-gel auto-combustion method was applied for preparation of SrFe12O19 magnetic nanoparticles (MNPs). Then, the prepared SrFe12O19 was analyzed by VSM, FT-IR, SEM, N-2 adsorption-desorption and XRD pattern. According to the hysteresis loops of SrFe12O19 MNPs, its magnetic saturation was about 79emu/g and also it is a typical feature of ferromagnetic compound. SEM image showed semi-spherical particles with average size of 70nm. The BET surface area of SrFe12O19 MNPs was 10.4m(2)/g. Moreover, the catalytic activity of SrFe12O19 MNPs was tested for the first time toward the Betti reaction. The results showed that it is an efficient catalyst which can be easily separated from the reaction mixture using an external magnet and gives the pure products in high yields within short reaction time.