(1R,2S,4R,7R,10S)-10-(4-chlorophenyl)sulfonyl-12,15-difluoro-4-methyl-17-oxa-5lambda6-thia-6-azatetracyclo[8.8.0.02,7.011,16]octadeca-11,13,15-triene 5,5-dioxide | 1104889-71-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (1R,2S,4R,7R,10S)-10-(4-chlorophenyl)sulfonyl-12,15-difluoro-4-methyl-17-oxa-5lambda6-thia-6-azatetracyclo[8.8.0.02,7.011,16]octadeca-11,13,15-triene 5,5-dioxide
• 英文别名: (1R,2S,4R,7R,10S)-10-(4-chlorophenyl)sulfonyl-12,15-difluoro-4-methyl-17-oxa-5λ6-thia-6-azatetracyclo[8.8.0.02,7.011,16]octadeca-11,13,15-triene 5,5-dioxide
• CAS: 1104889-71-5
• 化学式: C₂₂H₂₂ClF₂NO₅S₂
• 分子量: 518.002
• InChiKey: WYQBTXPCLPTKGS-XOCNHOQBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  33
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS
  申请人：Sasikumar Thavalakulamgara K.

  公开号：US20110110948A1

  公开（公告）日：2011-05-12

  Disclosed are novel gamma secretase inhibitors of the formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, wherein L 1 , n, X, Ar, Y, Z, Q, and Q 1 are as defined herein. Also disclosed are methods for inhibiting gamma secretase, methods for treating Alzheimer's disease, methods of treating one or more neurodegenerative diseases, and methods of inhibiting the deposition of amyloid protein (e.g., amyloid beta protein) in, on or around neurological tissue (e.g., the brain) using the compounds of formula 1.0.