(5S)-1'-[(3,5-dimethylphenyl)methyl]-6,8-dimethoxy-5-methyl-2-(2-methylprop-2-enyl)spiro[5,10-dihydroimidazo[1,5-b][2]benzazepine-3,4'-piperidine]-1-one | 1155773-25-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (5S)-1'-[(3,5-dimethylphenyl)methyl]-6,8-dimethoxy-5-methyl-2-(2-methylprop-2-enyl)spiro[5,10-dihydroimidazo[1,5-b][2]benzazepine-3,4'-piperidine]-1-one
• CAS: 1155773-25-3
• 化学式: C₃₂H₄₁N₃O₃
• 分子量: 515.696
• InChiKey: BIKHMPHPJSDKCL-DEOSSOPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  45.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1'-[(3,5-Dimethylphenyl)methyl]-6,8-dimethoxy-5-methyl-2-(2-methylprop-2-enyl)spiro[5,10-dihydroimidazo[1,5-b][2]benzazepine-3,4'-piperidine]-1-one 以 正庚烷 、 异丙醇 为溶剂， 以38%的产率得到(5S)-1'-[(3,5-dimethylphenyl)methyl]-6,8-dimethoxy-5-methyl-2-(2-methylprop-2-enyl)spiro[5,10-dihydroimidazo[1,5-b][2]benzazepine-3,4'-piperidine]-1-one
  参考文献：
  名称：

  [EN] METHOD OF MAKING IMIDAZOAZEPINONE COMPOUNDS
  [FR] PROCÉDÉ DE FABRICATION DE COMPOSÉS IMIDAZOAZÉPINONES

  摘要：

  通过以下步骤制备化合物I的方法：(a)提供化合物II或III：其中环A为C3-14芳基或C3-14杂芳基，如苯基或呋喃基；然后(b)将化合物II或III与酸结合以产生化合物I。

  公开号：

  WO2009070305A1

文献信息

• [EN] METHOD OF MAKING IMIDAZOAZEPINONE COMPOUNDS<br/>[FR] PROCÉDÉ DE FABRICATION DE COMPOSÉS IMIDAZOAZÉPINONES
  申请人：EISAI E & D MAN CO LTD

  公开号：WO2009070305A1

  公开（公告）日：2009-06-04

  A method of making a compound of Formula I: is carried out by (a) providing a compound of Formula (II) or (III): wherein ring A is C3-14 aryl or C3-14 heteroaryl such as phenyl or furanyl, and then (b) combining the compound of Formula (II) or (III) with an acid to produce a compound of Formula I.

  通过以下步骤制备化合物I的方法：(a)提供化合物II或III：其中环A为C3-14芳基或C3-14杂芳基，如苯基或呋喃基；然后(b)将化合物II或III与酸结合以产生化合物I。
• ENANTIOMERICALLY ENRICHED IMIDAZOAZEPINONE COMPOUNDS
  申请人：Spyvee Mark

  公开号：US20090197867A1

  公开（公告）日：2009-08-06

  The present invention provides an enantiomerically pure compound of Formula I: along with pharmaceutical formulations containing the same and methods of use thereof.
• METHODS OF USE
  申请人：Chen Qian

  公开号：US20100305098A1

  公开（公告）日：2010-12-02

  A method of treating a disorder such as rheumatoid arthritis or multiple sclerosis in a subject is carried out by administering to the subject a composition comprising a modulator compound of Th1 differentiation or Th17 expansion.
• METHOD OF MAKING IMIDAZOAZEPINONE COMPOUNDS
  申请人：Spyvee Mark

  公开号：US20110065916A1

  公开（公告）日：2011-03-17

  A method of making a compound of Formula I: is carried out by (a) providing a compound of Formula (II) or (III): wherein ring A is C3-14 aryl or C3-14 heteroaryl such as phenyl or furanyl, and then (b) combining the compound of Formula (II) or (III) with an acid to produce a compound of Formula I.
• [EN] METHODS OF USE<br/>[FR] PROCÉDÉS D'UTILISATION
  申请人：EISAI E & D MAN CO LTD

  公开号：WO2009064431A1

  公开（公告）日：2009-05-22

  A method of treating a disorder such as rheumatoid arthritis or multiple sclerosis in a subject is carried out by administering to the subject a composition comprising a modulator compound of Th1 differentiation or Th17 expansion.