(R_s)-N-[(S)-7-methoxy-1,2-dihydronaphthalen-1-yl]-2-methylpropane-2-sulfinamide | 1446434-17-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (R_s)-N-[(S)-7-methoxy-1,2-dihydronaphthalen-1-yl]-2-methylpropane-2-sulfinamide
• CAS: 1446434-17-8
• 化学式: C₁₅H₂₁NO₂S
• 分子量: 279.403
• InChiKey: HQXUHNFJDJZEAS-IFXJQAMLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.21
• 重原子数：
  19.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  38.33
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  (Rs)-N-[(S)-1-(5-methoxy-2-vinylphenyl)but-3-en-1-yl]-2-methylpropane-2-sulfinamide 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以80%的产率得到(R_s)-N-[(S)-7-methoxy-1,2-dihydronaphthalen-1-yl]-2-methylpropane-2-sulfinamide
  参考文献：
  名称：

  Asymmetric Allylation/Ring Closing Metathesis: One-Pot Synthesis of Benzo-fused Cyclic Homoallylic Amines. Application to the Formal Synthesis of Sertraline Derivatives

  摘要：

  A one-pot asymmetric allylation/ring closing metathesis (RCM) sequence for the synthesis of cyclic homoallylic amines has been developed. A library of six- and seven-membered benzo-fused products has been synthesized in good yields and complete diastereoselectivity. The new methodology has been applied to the formal syntheses of the antidepressant Sertraline and the epimeric Norsertraline. The methodology is amenable for the synthesis of analogs.

  DOI：

  10.1021/ol4017113