7,8-Dimethoxy-1,2,2a,3,4,5-hexahydro-3-aza-acenaphthylene | 26709-68-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 7,8-Dimethoxy-1,2,2a,3,4,5-hexahydro-3-aza-acenaphthylene
• 英文别名: 10,11-Dimethoxy-5-azatricyclo[6.3.1.04,12]dodeca-1(12),8,10-triene
• CAS: 26709-68-2
• 化学式: C₁₃H₁₇NO₂
• 分子量: 219.283
• InChiKey: BUJOJSDXNUBLPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 5-HT7 Receptor antagonists
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1676840A1

  公开（公告）日：2006-07-05

  The invention relates to compounds of structure (I) having pharmacological activity towards the 5-HT7 receptor, and more particularly to some 2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

  该发明涉及具有结构（I）的化合物，对5-HT7受体具有药理活性，更具体地涉及一些2,2a,4,5-四氢-1H-3-氮杂蒽烯取代磺酰胺化合物，制备这些化合物的方法，包含它们的药物组合物，以及它们用于治疗和/或预防涉及5-HT的疾病，如中枢神经系统疾病。
• 5-HT7 receptor antagonists
  申请人：Jover Torrens Antoni

  公开号：US20060142321A1

  公开（公告）日：2006-06-29

  The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some some 2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

  本发明涉及具有对5-HT7受体的药理活性的化合物，更特别地涉及一些2,2a,4,5-四氢-1H-3-氮杂蒽取代磺酰胺化合物，以及制备这些化合物的方法，包括它们的制药组合物和它们用于治疗和/或预防5-HT参与的疾病，如中枢神经系统疾病。
• 5-Ht7 Receptor Antagonists
  申请人：Torrens Jover Antoni

  公开号：US20090036480A1

  公开（公告）日：2009-02-05

  The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some 2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

  该发明涉及具有对5-HT7受体具有药理活性的化合物，更具体地涉及一些2,2a,4,5-四氢-1H-3-氮杂蒽基取代磺酰胺化合物，制备这些化合物的过程，包含它们的制药组合物以及它们用于治疗和/或预防5-HT参与的疾病，如中枢神经系统疾病的用途。
• 5-HT7 RECEPTOR ANTAGONISTS
  申请人：Jover Antoni Torrens

  公开号：US20090264458A1

  公开（公告）日：2009-10-22

  The invention relates to compounds having pharmacological activity towards the 5-receptor, and more particularly to some 2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

  本发明涉及具有对5-HT受体具有药理活性的化合物，更具体地涉及一些2,2a,4,5-四氢-1H-3-氮杂蒽取代磺酰胺化合物，制备这些化合物的方法，包含它们的制药组合物，以及它们用于治疗和/或预防5-HT参与的疾病，如中枢神经系统疾病的用途。
• US7553965B2
  申请人：——

  公开号：US7553965B2

  公开（公告）日：2009-06-30