8-(2-propynyl)-5-phenyl-6,7,8,9-tetrahydro-1H-pyrrolo-[3,2-h]-isoquinoline-2,3-dione-3-oxime | 309711-55-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 8-(2-propynyl)-5-phenyl-6,7,8,9-tetrahydro-1H-pyrrolo-[3,2-h]-isoquinoline-2,3-dione-3-oxime
• 英文别名: 3-(hydroxyamino)-5-phenyl-8-prop-2-ynyl-7,9-dihydro-6H-pyrrolo[3,2-h]isoquinolin-2-one
• CAS: 309711-55-5
• 化学式: C₂₀H₁₇N₃O₂
• 分子量: 331.374
• InChiKey: DRWYVHNVNRRIPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  64.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
  申请人：——

  公开号：US20020058663A1

  公开（公告）日：2002-05-16

  This invention relates to the use of compounds capable of inhibiting the activity of a proton-gated cation channel in the treatment or aleviation of diseases or disorders associated with, or mediated by a drop in extracellular pH.

  本发明涉及使用能够抑制质子门控阳离子通道活性的化合物来治疗或缓解与细胞外pH下降相关或介导的疾病或障碍。
• INHIBITORS OF PROTON-GATED CATION CHANNELS AND THEIR USE IN THE TREATMENT OF ISCHAEMIC DISORDERS
  申请人：NEUROSEARCH A/S

  公开号：EP1183025A2

  公开（公告）日：2002-03-06
• US6727260B2
  申请人：——

  公开号：US6727260B2

  公开（公告）日：2004-04-27
• US7288653B2
  申请人：——

  公开号：US7288653B2

  公开（公告）日：2007-10-30
• [EN] INHIBITORS OF PROTON-GATED CATION CHANNELS AND THEIR USE IN THE TREATMENT OF ISCHAEMIC DISORDERS<br/>[FR] INHIBITEURS DE CANAUX CATIONIQUES A PORTE PROTONIQUE ET LEUR UTILISATION POUR LE TRAITEMENT DE TROUBLES ISCHEMIQUES
  申请人：NEUROSEARCH AS

  公开号：WO2000071102A2

  公开（公告）日：2000-11-30

  This invention relates to the use of compounds capable of inhibiting the activity of a proton-gated cation channel in the treatment or alleviation of diseases or disorders associated with, or mediated by a drop in extracellular pH.