N-methyl-N-[4'-(2,4-dioxothiazolidin-5-yl-methyl)biphenyl-3-ylmethyl]-6-propoxynaphthalene-2-carboxamide | 561013-49-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-methyl-N-[4'-(2,4-dioxothiazolidin-5-yl-methyl)biphenyl-3-ylmethyl]-6-propoxynaphthalene-2-carboxamide
• 英文别名: 6-(propyloxy)-N-[4'-(2,4-dioxothiazolidin-5-ylmethyl)biphenyl-3-ylmethyl]-N-methylnaphthalene-2-carboxamide；N-[[3-[4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenyl]phenyl]methyl]-N-methyl-6-propoxynaphthalene-2-carboxamide
• CAS: 561013-49-8
• 化学式: C₃₂H₃₀N₂O₄S
• 分子量: 538.667
• InChiKey: NRUQOOJFHBPARR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Biaromatic ligand activators of PPARgamma receptors
  申请人：——

  公开号：US20030134885A1

  公开（公告）日：2003-07-17

  Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPAR&ggr; receptor, such biaromatic ligand having the structural formula (I): 1 and are well suited, inter alia, for regulating and/or restoring skin lipid metabolism, for treating a wide variety of dermatological afflictions, and for preventing and/or treating the signs of aging and/or dry skin.

  新型的制药/化妆品组合物至少包含一种PPAR&ggr;受体的双芳香配体激活剂，该双芳香配体具有结构式(I):1，并且非常适合调节和/或恢复皮肤脂质代谢，治疗各种皮肤病症，以及预防和/或治疗衰老和/或干燥皮肤的迹象。
• Biaromatic ligand activators of PPARGAMMA receptors
  申请人：Bernardon Jean-Michel

  公开号：US20070043046A1

  公开（公告）日：2007-02-22

  Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPARγ receptor, such biaromatic ligand having the structural formula (I): and are well suited, inter alia, for regulating and/or restoring skin lipid metabolism, for treating a wide variety of dermatological afflictions, and for preventing and/or treating the signs of aging and/or dry skin.

  新型药物/化妆品组合物包含至少一种PPARγ受体的双芳香基配体激活剂，该双芳香基配体具有结构式（I）并且非常适合调节和/或恢复皮肤脂质代谢，用于治疗各种皮肤病症和预防和/或治疗衰老和/或干燥皮肤的迹象。
• BIPHENYLMETHYL-THIAZOLIDINEDIONES ET ANALOGUES ET LEUR UTILISATION COMME ACTIVATEUR PPAR-GAMMA
  申请人：Galderma Research & Development, S.N.C.

  公开号：EP1458697B1

  公开（公告）日：2006-09-06
• UTILISATION D`ACTIVATEURS DE RECEPTEURS PPAR EN COSMETIQUE ET DERMATOLOGIE
  申请人：Galderma Research & Development, S.N.C.

  公开号：EP1722753A2

  公开（公告）日：2006-11-22
• Cosmetic/dermatological applications of PPAR receptor activators
  申请人：Jomard Andre

  公开号：US20070065471A1

  公开（公告）日：2007-03-22

  Cosmetic/pharmaceutical compositions useful for regulating the size of sebaceous glands and, in particular, for inhibiting sebum production, or for treating pathologies entailing an overproduction of sebum, or for treating greasy skin and/or a scalp prone to dandruff, contain thus effective amounts of at least one activator of PPAR type receptors.