bis-{3-O-[(3H-naphtho[2,1-b]pyran-3-on-2-yl)methyl]-β-D-galactopyranosyl}sulfane | 1448779-66-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: bis-{3-O-[(3H-naphtho[2,1-b]pyran-3-on-2-yl)methyl]-β-D-galactopyranosyl}sulfane
• 英文别名: 2-[[(2S,3R,4S,5S,6R)-2-[(2S,3R,4S,5S,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(3-oxobenzo[f]chromen-2-yl)methoxy]oxan-2-yl]sulfanyl-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxymethyl]benzo[f]chromen-3-one
• CAS: 1448779-66-5
• 化学式: C₄₀H₃₈O₁₄S
• 分子量: 774.799
• InChiKey: PDAWYSRIVYXOTR-FERXABOLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  55
• 可旋转键数：
  10
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  236
• 氢给体数：
  6
• 氢受体数：
  15

文献信息

• [EN] SELENOGALACTOSIDE COMPOUNDS FOR THE TREATMENT OF SYSTEMIC INSULIN RESISTANCE DISORDERS AND THE USE THEREOF<br/>[FR] COMPOSÉS DE SÉLÉNOGALACTOSIDE POUR LE TRAITEMENT DE TROUBLES DE LA RÉSISTANCE SYSTÉMIQUE À L'INSULINE ET LEUR UTILISATION
  申请人：GALECTIN SCIENCES LLC

  公开号：WO2019089080A9

  公开（公告）日：2020-07-23
• NOVEL GALACTOSIDE INHIBITORS OF GALECTINS
  申请人：Galecto Biotech AB

  公开号：EP2807176B1

  公开（公告）日：2015-12-30
• Novel galectoside inhibitors of galectins
  申请人：GALECTO BIOTECH AB

  公开号：US20140336146A1

  公开（公告）日：2014-11-13

  The present invention relates to novel compounds prepared from readily accessible 3-O-propargyl-D-galactopyranoside derivatives and having an effect as i.a., galectin inhibitors, the use of said compounds as a medicament as well as for the manufacture of a medicament for treatment of disorders relating to the binding of galectin to ligands in a mammal, wherein said galectin is preferably a galectin-3. The novel compounds are defined by the general formula (I).
• US9353141B2
  申请人：——

  公开号：US9353141B2

  公开（公告）日：2016-05-31