3-aminophenyl 4-methylpiperazine-1-carboxylate | 932405-35-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-aminophenyl 4-methylpiperazine-1-carboxylate
• 英文别名: (3-Aminophenyl) 4-methylpiperazine-1-carboxylate
• CAS: 932405-35-1
• 化学式: C₁₂H₁₇N₃O₂
• 分子量: 235.286
• InChiKey: ISBHKWJUUJQKHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  58.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-nitrophenyl 4-methylpiperazine-1-carboxylate 在 5%-palladium/activated carbon 氢气 作用下， 以 甲醇 为溶剂， 以81%的产率得到3-aminophenyl 4-methylpiperazine-1-carboxylate
  参考文献：
  名称：

  [EN] DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
  [FR] COMPOSES ET COMPOSITIONS CONTENANT DE LA DIARYLAMINE, ET UTILISATION EN TANT QUE MODULATEURS DE RECEPTEURS DE C-KIT

  摘要：

  公开号：

  WO2007038669A3

文献信息

• DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
  申请人：Molteni Valentina

  公开号：US20090012094A1

  公开（公告）日：2009-01-08

  Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

  本文介绍了一种包含二芳胺结构特征的化合物。还介绍了制备这种化合物的方法，使用这种化合物调节c-kit受体活性的方法，以及包含这种化合物的制药组合物和药物。本文还介绍了使用这种化合物、制药组合物和药物治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或状况的方法。
• Diarylamine-Containing Compounds and Compositions, and their use as Modulators of C-Kit Receptors
  申请人：Molteni Valentina

  公开号：US20070149538A1

  公开（公告）日：2007-06-28

  Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

  本文描述了包含二芳胺结构特征的化合物。还描述了制备这种化合物的方法，使用这种化合物调节c-kit受体活性的方法，以及包含这种化合物的药物组合物和药物。本文还描述了使用这种化合物、药物组合物和药物治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或状况的方法。
• US7563894B2
  申请人：——

  公开号：US7563894B2

  公开（公告）日：2009-07-21
• US7514447B2
  申请人：——

  公开号：US7514447B2

  公开（公告）日：2009-04-07
• US7592349B2
  申请人：——

  公开号：US7592349B2

  公开（公告）日：2009-09-22