(2R,3S)-3-(1H-indol-3-yl)-2-{[(6-methyl-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]amino}butanoic acid | 697305-14-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: (2R,3S)-3-(1H-indol-3-yl)-2-{[(6-methyl-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]amino}butanoic acid
• 英文别名: (2R,3S)-3-(1H-indol-3-yl)-2-[(6-methyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)amino]butanoic acid
• CAS: 697305-14-9
• 化学式: C₂₃H₂₅N₃O₃
• 分子量: 391.47
• InChiKey: KEEVJVLXPMEUBA-YCRPNKLZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  85.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Indole derivatives as somatostatin agonists or antagonists
  申请人：Abe Hidenori

  公开号：US20060223826A1

  公开（公告）日：2006-10-05

  The present invention provide a compound of the formula (I) wherein ring A represents an aromatic ring optionally having substituents; B, Y and Ya are the same or different and each represents a bond, etc.; R 1 and R 2 are the same or different and each represents a hydrogen atom, etc.; R 3 represents a hydrogen atom, etc.; R 4 and R 5 are the same or different and each represents a hydrogen, etc.; R 6 represents an indolyl group optionally having substituents; and Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibition activity and is useful for preventing and/or treating diseases associated with somatostatin.

  本发明提供了一种化合物(I)的公式，其中环A代表一种芳香环，可选地具有取代基; B、Y和Ya相同或不同，每个代表一种键等; R1和R2相同或不同，每个代表一个氢原子等; R3代表一个氢原子等; R4和R5相同或不同，每个代表一个氢等; R6代表一种吲哚基，可选地具有取代基; Z和Za相同或不同，每个代表一个氢原子等; 或其盐或前药，具有生长抑素受体结合抑制活性，并用于预防和/或治疗与生长抑素相关的疾病。