(1R,2S)-2-carboxymethylamino-1,2-diphenylethanol | 108865-56-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (1R,2S)-2-carboxymethylamino-1,2-diphenylethanol
• 英文别名: 2-[[(1S,2R)-2-hydroxy-1,2-diphenylethyl]amino]acetic acid
• CAS: 108865-56-1
• 化学式: C₁₆H₁₇NO₃
• 分子量: 271.316
• InChiKey: GZQBQURPFATDQM-JKSUJKDBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Sodium; ((1S,2R)-2-hydroxy-1,2-diphenyl-ethylamino)-acetate 生成 (1R,2S)-2-carboxymethylamino-1,2-diphenylethanol
  参考文献：
  名称：

  XASEHGAVA, MASAKI;SAJGO, KADZUXIKO;YUKI, JOITI;TATIBAKA, KODZO

  摘要：

  DOI：

文献信息

• Optically active carboalkylated amino alcohols and their utilization in
  申请人：Daicel Chemical Industries, Ltd.

  公开号：US04966985A1

  公开（公告）日：1990-10-30

  A carboalkylated amino alcohol having each of the below shown formulae is novel and optically active. A separating agent comprising the alcohol and a support is effectively useful to separate a variety of racemates for example with chromatography. The alcohol may be chemically or physically combined with the support. ##STR1## [wherein Ph represents a phenyl group, R represents a hydrogen atom, an alkyl group having the carbon number of 1 to 10, or an aryl group having the carbon number of 6 to 10, X represents an --0-- group or a --S-- group, and Z represents a hydrogen atom, an alkyl group having the carbon number of 1 to 10 or a metal element].

  一种具有以下示出的化学式的碳烷基化氨基醇是新颖的且具有光学活性。包括该醇和一种载体的分离剂可有效地用于分离各种外消旋体，例如通过色谱法。该醇可以与载体在化学或物理上结合。[其中Ph代表苯基，R代表氢原子，碳数为1至10的烷基基团，或碳数为6至10的芳基基团，X代表--O--基团或--S--基团，Z代表氢原子，碳数为1至10的烷基基团或金属元素]。
• Utilisation of optically active carboalkylated amino alcohols in optical resolution
  申请人：DAICEL CHEMICAL INDUSTRIES, LTD.

  公开号：EP0231515A1

  公开（公告）日：1987-08-12

  A carboalkylated amino alcohol having each of the below shown formulae is novel and optically active. A separating agent comprising the alcohol and a support is effectively useful to separate a variety of racemates for example with chromatography. The alcohol may be chemically or physically combined with the support. [wherein Ph represents a phenyl group, R represents a hydrogen atom, an alkyl group having the carbon number of 1 to 10, or an aryl group having the carbon number of 6to 10, X represents an-0- group or a-S- group, and Z represents a hydrogen atom, an alkyl group having the carbon number of 1 to 10 or a metal element]

  具有以下各式的羧烷基化氨基醇是一种新颖且具有光学活性的物质。 由该醇和载体组成的分离剂可有效用于分离各种外消旋体，例如色谱法。 该醇可与载体化学或物理结合。 [其中 Ph 代表苯基，R 代表氢原子、碳原子数为 1 至 10 的烷基或碳原子数为 6 至 10 的芳基，X 代表 0-基团或 S-基团，Z 代表氢原子、碳原子数为 1 至 10 的烷基或金属元素] [其中 Ph 代表苯基，R 代表氢原子、碳原子数为 1 至 10 的烷基或碳原子数为 6 至 10 的芳基，X 代表 0-基团或 S-基团，Z 代表氢原子、碳原子数为 1 至 10 的烷基或金属元素]。
• Optically pure cis-oxalato(trans-l-1,2-cyclohexanediamine)Pt(II) and process for resolving optical isomers of a platinum complex compound
  申请人：Tanaka Kikinzoku Kogyo K.K.

  公开号：EP0567438A1

  公开（公告）日：1993-10-27

  A process of optically resolving an optically active platinum complex compound consisting of a mixture of a d-isomer and an I-isomer uses high performance liquid chromatography employing a column packed with a chiral filler. The chiral filler may be, for example, a cellulose ester derivative, a cellulose carbamate derivative, an amylose carbamate derivative, a polymethacryl acid ester andβ-and-γ-cyclodextrin. An optically pure cis-oxalato (trans-1-1,2-cyclohexanediamine) Pt(II) separated from a d-isomer by the process of the invention is found to be remarkably effective as a raw material for preparing a carcinostatic agent. Complete optical purity of the compound reflects in a lower melting point of the substance as compared with that of an impure substance.

  一种光学解析由 d-异构体和 I-异构体混合物组成的具有光学活性的铂络合物的工艺，采用了高效液相色谱法，在色谱柱中填充了手性填料。 例如，手性填料可以是纤维素酯衍生物、氨基甲酸纤维素衍生物、氨基甲酸淀粉衍生物、聚甲基丙烯酸酯和β-和γ-环糊精。 通过本发明的工艺从 d-异构体中分离出的光学纯顺式草酸（反式-1-1,2-环己二胺）铂(II)，作为制备致癌剂的原料效果显著。 该化合物的完全光学纯度反映了该物质的熔点低于不纯物质的熔点。
• Cis-oxalato(trans-L-1,2-cyclohexanediamine) Pt(II) complex having high optical purity and process of preparing same
  申请人：Tanaka Kikinzoku Kogyo K.K.

  公开号：EP0625523A1

  公开（公告）日：1994-11-23

  Disclosed is cis-oxalato(trans-l-1,2-cyclohexanediamine) Pt(II) complex having high optical purity and no toxicity and exhibiting anticancer performance, as shown in the below Formula. Cis-oxalato(trans-l-1,2-cyclohexanediamine) Pt(II) complex of the invention possesses high optical purity of 99.94 % or more e.e. and a melting point of 198.3 to 199.7 °C. The complex is synthesized employing as starting material trans-l-1,2-cyclohexamediamine or a derivative of the trans-l-1,2-cyclohexanediamine optically resoluted by means of a high performance liquid chromatography.

  本发明公开了具有高光学纯度和无毒性并具有抗癌性能的顺式-氧杂羰基(反式-l-1,2-环己二胺)铂(II)络合物，如下式所示。 本发明的顺式-草酰氧基（反式-l-1,2-环己二胺）铂(II)络合物的光学纯度高达 99.94 % 或以上，熔点为 198.3 至 199.7 ℃。该络合物的合成是以反式-l-1,2-环己二胺或反式-l-1,2-环己二胺的衍生物为起始原料，通过高效液相色谱法进行光学解析。
• US4966985A
  申请人：——

  公开号：US4966985A

  公开（公告）日：1990-10-30