6-(3-Adamantan-1-yl-5-bromo-4-hydroxyphenyl)-naphthalene-2-carboxylic acid | 353264-56-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-(3-Adamantan-1-yl-5-bromo-4-hydroxyphenyl)-naphthalene-2-carboxylic acid
• 英文别名: 6-[3-(1-Adamantyl)-5-bromo-4-hydroxyphenyl]naphthalene-2-carboxylic acid
• CAS: 353264-56-9
• 化学式: C₂₇H₂₅BrO₃
• 分子量: 477.398
• InChiKey: PVMIZWUTVYLWJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Retinoid compounds suited for antibacterial applications
  申请人：——

  公开号：US20030055110A1

  公开（公告）日：2003-03-20

  A variety of retinoid compounds well suited for preventively or curatively treating a bacterial colonization infesting/infecting an individual subject exhibit pronounced antibacterial activity, notably pronounced antibacterial activity in respect of the bacterium Staphylococcus aureus , and are also well suited for the cleansing/deodorizing of human skin.

  一系列适合于预防或治疗细菌感染的视黄醇类化合物表现出显著的抗菌活性，特别是对于金黄色葡萄球菌这种细菌表现出显著的抗菌活性，并且也适合于清洁/除臭人类皮肤。
• UTILISATION DE COMPOSES DE TYPE RETINOIDES EN TANT QU'AGENTS ANTI-BACTERIENS CONTRE STAPHYLOCOCCUS AUREUS
  申请人：GALDERMA RESEARCH & DEVELOPMENT

  公开号：EP1255543B1

  公开（公告）日：2010-09-01
• USE OF COLLAGEN BINDING DOMAINS TO DELIVER PRODUCTS TO SKIN
  申请人：Fabius Biotechnology

  公开号：US20210338558A1

  公开（公告）日：2021-11-04

  The present invention addresses the need for an improved delivery system that is able to specifically target the skin for improved bioavailability and minimization of side effects resulting from administration of the active ingredient or ingredients. One aspect of the present invention is a targeting composition comprising: (1) a skin care agent or an agent that is a cosmeceutical agent; (2) an intermediate release linker bound to the skin care agent or cosmeceutical agent; (3) a targeting moiety bound to the intermediate release linker, the targeting moiety for binding the targeting composition to native collagen fibers; and (4) optionally, a carrier component to enhance delivery to the skin. The present invention also describes methods of use of these targeting compositions.
• US6858647B2
  申请人：——

  公开号：US6858647B2

  公开（公告）日：2005-02-22
• [EN] USE OF COLLAGEN BINDING DOMAINS TO DELIVER PRODUCTS TO SKIN<br/>[FR] UTILISATION DE DOMAINES DE LIAISON AU COLLAGÈNE POUR DÉLIVRER DES PRODUITS À LA PEAU
  申请人：FABIUS BIOTECHNOLOGY

  公开号：WO2020068665A1

  公开（公告）日：2020-04-02

  The present invention addresses the need for an improved delivery system that is able to specifically target the skin for improved bioavailability and minimization of side effects resulting from administration of the active ingredient or ingredients. One aspect of the present invention is a targeting composition comprising: (1 ) a skin care agent or an agent that is a cosmeceutical agent; (2) an intermediate release linker bound to the skin care agent or cosmeceutical agent; (3) a targeting moiety bound to the intermediate release linker, the targeting moiety for binding the targeting composition to native collagen fibers; and (4) optionally, a carrier component to enhance delivery to the skin. The present invention also describes methods of use of these targeting compositions.