2-Methoxy-5-(5,6,7-trimethoxy-3,4-dihydronaphthalen-1-yl)phenol | 917591-61-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Methoxy-5-(5,6,7-trimethoxy-3,4-dihydronaphthalen-1-yl)phenol
• CAS: 917591-61-8
• 化学式: C₂₀H₂₂O₅
• 分子量: 342.4
• InChiKey: DCSQMMULZSZITH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Combretastatin analogs with tubulin binding activity
  申请人：Pinney G. Kevin

  公开号：US20060293394A1

  公开（公告）日：2006-12-28

  Analogs of combretastatin have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.

  已经发现了与康柏他斯汀类似的化合物，它们展示出令人印象深刻的细胞毒性，以及抑制微管聚合的显著能力。这些化合物是治疗人类癌症的优秀临床候选药物。此外，这些配体中的某些作为前药，很可能证明是肿瘤选择性血管靶向化疗药物，或具有血管靶向活性，导致选择性预防和/或破坏非恶性增殖的血管。
• Combretastatin Analogs with Tubulin Binding Activity
  申请人：PINNEY Kevin G.

  公开号：US20090075943A1

  公开（公告）日：2009-03-19

  Analogs of combretastatin have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.

  已经发现了类似于合成静癌素的物质，表现出令人印象深刻的细胞毒性，以及抑制微管聚合的显著能力。这些化合物是治疗人类癌症的优秀临床候选药物。此外，其中某些配体作为前药，可能被证明是肿瘤选择性血管靶向化疗药物，或具有靶向血管活性，导致非恶性增生血管的选择性预防和/或破坏。
• COMBRETASTATIN ANALOGS WITH TUBULIN BINDING ACTIVITY
  申请人：BAYLOR UNIVERSITY

  公开号：EP1896391B1

  公开（公告）日：2015-08-12
• US7429681B2
  申请人：——

  公开号：US7429681B2

  公开（公告）日：2008-09-30
• US8394859B2
  申请人：——

  公开号：US8394859B2

  公开（公告）日：2013-03-12