(benzofuryl-2) methane phosphonate de diethyle | 42999-44-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (benzofuryl-2) methane phosphonate de diethyle
• 英文别名: 2-(Diethoxyphosphorylmethyl)-1-benzofuran
• CAS: 42999-44-0
• 化学式: C₁₃H₁₇O₄P
• 分子量: 268.249
• InChiKey: NUYVYQVDHXHGRT-UHFFFAOYSA-N

物化性质

• 沸点：
  380.1±25.0 °C(Predicted)
• 密度：
  1.189±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  48.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (benzofuryl-2) methane phosphonate de diethyle 在 盐酸 作用下， 反应 6.0h， 以64%的产率得到acide (benzofuryl-2) methane phosphonique
  参考文献：
  名称：

  Mouysset; Bellan; Payard, Farmaco, Edizione Pratica, 1987, vol. 42, # 11, p. 805 - 813

  摘要：

  DOI：
• 作为产物：
  描述：

  苯并呋喃-2-羧酸 在 lithium aluminium tetrahydride 、 氯化亚砜 作用下， 以 乙醚 、 甲苯 为溶剂， 反应 18.0h， 生成 (benzofuryl-2) methane phosphonate de diethyle
  参考文献：
  名称：

  Mouysset; Bellan; Payard, Farmaco, Edizione Pratica, 1987, vol. 42, # 11, p. 805 - 813

  摘要：

  DOI：

文献信息

• STYRYLBENZOFURAN DERIVATIVES AS INHIBITORS FOR BETA-AMYLOID FIBRIL FORMATION AND PREPARATION METHOD THEREOF
  申请人：Kim Dong Jin

  公开号：US20110124888A1

  公开（公告）日：2011-05-26

  The present invention relates to a novel compound which efficiently inhibits the formation of beta-amyloid fibrils in the brain to be useful for preventing or treating a degenerative brain disease, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.

  本发明涉及一种新型化合物，能够有效抑制大脑中β-淀粉样蛋白纤维的形成，可用于预防或治疗退行性脑疾病，以及制备该化合物的方法和包含其作为活性成分的药物组合物。
• 一种化合物以及含有该化合物的有机电致发光元件用材料、有机电致发光装置和电子设备
  申请人：北京八亿时空液晶科技股份有限公司

  公开号：CN113024444A

  公开（公告）日：2021-06-25

  本发明涉及式(I)的化合物，该化合物适用于电子元件中，特别是适用于有机电致发光元件中，并且涉及含有所述化合物的电子元件。
• Process for Producing Polyester, Polyester Produced Using Said Process, and Polyester Molded Product
  申请人：Kageyama Katsuhiko

  公开号：US20080249280A1

  公开（公告）日：2008-10-09

  This invention provides a polyester and a polyester molded product, which, while maintaining color tone, transparency, and thermal stability, can realize a high polycondensation rate, are less likely to cause the production of polycondensation catalyst-derived undesired materials, and can simultaneously meet both quality and cost effectiveness requirements, which can exhibit the characteristic features, for example, in the fields of ultrafine fibers, high transparent films for optical use, or ultrahigh transparent molded products. These advantages can be realized by using, in the production of a polyester in the presence of an aluminum compound-containing polyester polycondensation catalyst, an aluminum compound having an absorbance of not more than 0.0132 as measured in the form of an aqueous aluminum compound solution, prepared by dissolving the aluminum compound in pure water to give a concentration of 2.7 g/liter in terms of the amount of aluminum element, under conditions of cell length 1 cm and wavelength 680 nm.

  本发明提供了一种聚酯和聚酯成型产品，可以在保持色调、透明度和热稳定性的同时，实现高聚酯化速率，不太可能引起聚酯化催化剂来源的不良材料的生产，并且可以同时满足质量和成本效益的要求，这些优点可以在超细纤维、用于光学的高透明薄膜或超高透明成型产品等领域展现出特征性能。通过在含有铝化合物聚酯聚合催化剂的聚酯生产中使用具有吸光度不超过0.0132的铝化合物，可以实现这些优点。该吸光度是在细胞长度为1厘米，波长为680纳米的条件下，将铝化合物溶解在纯水中以给定铝元素量浓度为2.7克/升形成的水溶性铝化合物溶液中测量得出的。
• POLYESTER, PROCESS FOR PRODUCTION OF POLYESTER, AND POLYESTER MOLDED ARTICLE
  申请人：Toyo Boseki Kabushiki Kaisha

  公开号：EP1932867A1

  公开（公告）日：2008-06-18

  Disclosed is a polyester produced from an aluminum compound and a phosphorus compound in the presence of a polycondensation catalyst. The polyester contains a polyester-insoluble, aluminum-containing insoluble particle in an amount of 1000 ppm or less as quantified by the method disclosed in the description, and contains an acid terminal group at a ratio of 10 to 50 eq/ton. The polyester can provide a highly transparent molded article produced through drawing (e.g., a film or hollow molded article) and is useful in the fields of highly transparent optical films, ultra-highly transparent molded articles or the like.

  本发明公开了一种在缩聚催化剂存在下由铝化合物和磷化合物制得的聚酯。该聚酯含有聚酯不溶物、含铝不溶物颗粒，按描述中公开的方法定量，其含量为 1000 ppm 或更少，并含有酸性末端基团，其比例为 10 至 50 eq/吨。该聚酯可提供通过拉丝生产的高透明模塑品（如薄膜或中空模塑品），在高透明光学薄膜、超高透明模塑品等领域非常有用。
• The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists
  作者：Jay M. Matthews、Ning Qin、Raymond W. Colburn、Scott L. Dax、Mike Hawkins、James J. McNally、Laura Reany、Mark A. Youngman、Judith Baker、Tasha Hutchinson、Yi Liu、Mary Lou Lubin、Michael Neeper、Michael R. Brandt、Dennis J. Stone、Christopher M. Flores

  DOI：10.1016/j.bmcl.2012.02.060

  日期：2012.4

  A series of benzothiophene-based phosphonates was synthesized and many analogs within the series were shown to be potent antagonists of the TRPM8 channel. The compounds were obtained as a racemic mixture in 5 synthetic steps, and were tested for TRPM8 antagonist activity in a recombinant, canine TRPM8-expressing cell line using a fluorometric imaging plate reader (FLIPR) assay. Structure-activity relationships were developed initially by modification of the core structure and subsequently by variation of the aromatic substituents and the phosphonate ester. Compound 9l was administered intraperitoneally to rats and demonstrated engagement of the TRPM8 target in both prevention and reversalmodes in an icilin-induced 'wet-dog' shake model. (C) 2012 Published by Elsevier Ltd.