7-[(6-chloro-2-naphthalenyl)sulfonyl]tetrahydro-8a-(methoxymethyl)-1'-(phenylmethyl)-spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidin]-5(1H)-one | 318988-35-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-[(6-chloro-2-naphthalenyl)sulfonyl]tetrahydro-8a-(methoxymethyl)-1'-(phenylmethyl)-spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidin]-5(1H)-one
• 英文别名: (+/-)-7-[(6-chloronaphthalen-2-yl)sulfonyl]tetrahydro-8a-(methoxymethyl)-1'-(phenylmethyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidin]-5(1H)-one；1,4,7-triaza-1'-benzyl-4-(6-chloronaphthalen-2-ylsulfonyl)-6-(methoxymethyl)spiro[bicyclo[4.3.0]nonane-8,4'-piperidin]-2-one；1'-Benzyl-7-(6-chloronaphthalen-2-yl)sulfonyl-8a-(methoxymethyl)spiro[1,3,6,8-tetrahydroimidazo[1,2-a]pyrazine-2,4'-piperidine]-5-one
• CAS: 318988-35-1
• 化学式: C₂₉H₃₃ClN₄O₄S
• 分子量: 569.124
• InChiKey: GLLOCBDQAVIHPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  90.6
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Tricyclic compound having spiro union
  申请人：——

  公开号：US20030045520A1

  公开（公告）日：2003-03-06

  This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which exhibits strong anticoagulation action. 1 The invention also relates to a pharmacophore which was derived from the compound and is useful in molecular designing of the FXa inhibitor.

  本发明涉及具有以下式（I）所表示的螺联结的三环化合物或其盐，该化合物可用作药物，特别是作为激活的血液凝血因子X的抑制剂，可经口给药，具有强烈的抗凝作用。该发明还涉及从该化合物衍生的药效团，可用于FXa抑制剂的分子设计。
• Cholesterol biosynthesis inhibitors containing as the active ingredient tricyclic spiro compounds
  申请人：——

  公开号：US20040063716A1

  公开（公告）日：2004-04-01

  This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which exhibits strong anticoagulation action. 1 The invention also relates to a pharmacophore which was derived from the compound and is useful in molecular designing of the FXa inhibitor.

  本发明涉及具有spiro联合的三环化合物，其表示为以下公式(I)或其盐，可用作药物，特别是作为口服给药的激活血液凝血因子X的抑制剂，具有强烈的抗凝作用。此外，本发明还涉及从该化合物衍生的药效团，可用于FXa抑制剂的分子设计。
• Tricyclic Spiro Compound Comprising Acyl Group Bound to Nitrogen Atom in the Ring
  申请人：Nishida Hidemitsu

  公开号：US20090076015A1

  公开（公告）日：2009-03-19

  It is intended to provide an anticoagulant that has an extremely excellent FXa inhibitory action and an extremely weak hERG channel inhibitory action and can be orally administered, which is a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof.

  该文旨在提供一种极为优异的FXa抑制剂，具有极弱的hERG通道抑制作用，并可口服，该化合物由以下公式(I)所代表，或其药学上可接受的盐。
• TRICYCLIC COMPOUNDS HAVING SPIRO UNION
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP1191028A1

  公开（公告）日：2002-03-27

  This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which exhibits strong anticoagulation action. The invention also relates to a pharmacophore which was derived from the compound and is useful in molecular designing of the FXa inhibitor.

  本发明涉及具有下式(I)所代表的螺联的三环化合物或其盐，该化合物可用作药物，特别是活化的血液凝固因子 X 的抑制剂，可口服给药，并具有很强的抗凝作用。 本发明还涉及一种药理结构，该结构来源于该化合物，可用于 FXa 抑制剂的分子设计。
• TRICYCLIC SPIRO COMPOUND COMPRISING ACYL GROUP BOUND TO NITROGEN ATOM IN THE RING
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP1864984A1

  公开（公告）日：2007-12-12

  It is intended to provide an anticoagulant that has an extremely excellent FXa inhibitory action and an extremely weak hERG channel inhibitory action and can be orally administered, which is a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof.

  本研究旨在提供一种具有极佳的 FXa 抑制作用和极弱的 hERG 通道抑制作用且可口服的抗凝血剂，它是由下式（I）代表的化合物或其药学上可接受的盐。