2-ethoxy-3-{1-[2-(4-fluorophenoxy)ethyl]-2-oxo-1,2-dihydro-4-pyridinyl}propanoic acid | 467236-16-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 2-ethoxy-3-{1-[2-(4-fluorophenoxy)ethyl]-2-oxo-1,2-dihydro-4-pyridinyl}propanoic acid
• 英文别名: 2-Ethoxy-3-[1-[2-(4-fluorophenoxy)ethyl]-2-oxopyridin-4-yl]propanoic acid
• CAS: 467236-16-4
• 化学式: C₁₈H₂₀FNO₅
• 分子量: 349.359
• InChiKey: MXKVUDQIUNYFPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Carboxylic acids
  申请人：——

  公开号：US20040116708A1

  公开（公告）日：2004-06-17

  The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them. 1 In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C 1-6 alkyl group or a C 1-6 alkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III): 2 (wherein Z represents a group represented by the formula (IV): 3 (wherein R 9 , R 10 , R 11 and R 12 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C 1-6 alkyl group or a C 1-6 alkoxy group)); m is 0 or 1; and n is 0 or 1.

  本发明提供了一种新的羧酸衍生物，其盐或水合物可用作胰岛素增敏剂，并提供了一种以该衍生物为有效成分的药物。更具体地，本发明提供了一种由式(I)表示的羧酸化合物，其盐或水合物。在式中，Ar表示一个有6至14个成员的芳香环基团，该基团可以具有至少一个取代基；R1，R2，R3，R4，R5，R6，R7和R8相同或不同，每个表示氢原子，卤素原子，羟基，C1-6烷基或C1-6烷氧基；X表示氧原子或亚甲基；Y表示由式(II)或(III)表示的基团：其中Z表示由式(IV)表示的基团：其中R9，R10，R11和R12相同或不同，每个表示氢原子，卤素原子，羟基，C1-6烷基或C1-6烷氧基）；m为0或1；n为0或1。
• Benzene compound and salt thereof
  申请人：——

  公开号：US20040138271A1

  公开（公告）日：2004-07-15

  The present invention provides a medicament comprising a benzene compound useful as an insulin sensitizer, a salt thereof or a hydrate of them and a derivative of them as the active ingredient. Specifically, it provides a benzene compound represented by the following formula, a salt thereof or a hydrate of them. 1 In the formula, X represents 1) a C 6-10 aryl group which may have one or more substituents or 2) a 5- to 10-membered heteroaryl group which may have one or more substituents; Y represents a group represented by the formula: 2 (in the above formulae, R y1 , R y2 and R y3 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C 1-6 alkyl group, a C 1-6 alkoxy group, or a C 3-7 cycloalkyl group) etc.; Z represents a group represented by the formula: 3 (in the formula, m represents an integer of 0 to 2; R z1, R z2 , R z3 and R z4 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C 1-6 alkyl group, a C 1-6 alkoxy group, a C 3-7 cycloalkyl group, a halogenated C 1-6 alkyl group, a halogenated C 1-6 alkoxy group etc.); and R 1 , R 2 , R 3 and R 4 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C 1-6 alkyl group, a C 1-6 alkoxy group, a C 3-7 cycloalkyl group etc.

  本发明提供了一种药物，其包括一种苯化合物，其作为胰岛素增敏剂、其盐或其水合物以及其衍生物作为活性成分。具体而言，它提供了由以下公式表示的苯化合物，其盐或其水合物。其中，X代表1）可能具有一个或多个取代基的C6-10芳基基团或2）可能具有一个或多个取代基的5-至10元杂环芳基基团；Y代表由以下公式表示的基团：2（在上述公式中，Ry1、Ry2和Ry3彼此相同或不同，每个代表氢原子、卤原子、C1-6烷基、C1-6烷氧基或C3-7环烷基等）等；Z代表由以下公式表示的基团：3（在公式中，m表示0到2的整数；Rz1、Rz2、Rz3和Rz4彼此相同或不同，每个代表氢原子、卤原子、C1-6烷基、C1-6烷氧基、C3-7环烷基、卤代C1-6烷基、卤代C1-6烷氧基等）；R1、R2、R3和R4彼此相同或不同，每个代表氢原子、卤原子、C1-6烷基、C1-6烷氧基、C3-7环烷基等。
• BENZENE COMPOUND AND SALT THEREOF
  申请人：Eisai Co., Ltd.

  公开号：EP1375472A1

  公开（公告）日：2004-01-02

  The present invention provides a medicament comprising a benzene compound useful as an insulin sensitizer, a salt thereof or a hydrate of them and a derivative of them as the active ingredient. Specifically, it provides a benzene compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, X represents 1) a C6-10 aryl group which may have one or more substituents or 2) a 5- to 10-membered heteroaryl group which may have one or more substituents; Y represents a group represented by the formula: (in the above formulae, Ry1, Ry2 and Ry3 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, or a C3-7 cycloalkyl group) etc.; Z represents a group represented by the formula: (in the formula, m represents an integer of 0 to 2; Rz1, Rz2, Rz3 and Rz4 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C3-7 cycloalkyl group, a halogenated C1-6 alkyl group, a halogenated C1-6 alkoxy group etc.); and R1, R2, R3 and R4 are the same as or different from one another and each represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C3-7 cycloalkyl group etc.

  本发明提供了一种药物，其活性成分包括一种用作胰岛素增敏剂的苯化合物、其盐或它们的水合物以及它们的衍生物。具体地说，本发明提供了由下式表示的苯化合物、其盐或它们的水合物。 式中，X 代表 1）C6-10 芳基，可具有一个或多个取代基；或 2）5-10 元杂芳基，可具有一个或多个取代基；Y 代表由式表示的基团： (在上式中，Ry1、Ry2和Ry3彼此相同或不同，且各自代表氢原子、卤素原子、C1-6烷基、C1-6烷氧基或C3-7环烷基)等；Z代表由式： (式中，m 代表 0 至 2 的整数；Rz1、Rz2、Rz3 和 Rz4 彼此相同或不同，各自代表氢原子、卤素原子、C1-6 烷基、C1-6 烷氧基、C3-7 环烷基、卤代 C1-6 烷基、卤代 C1-6 烷氧基等）；以及 R1、R2、Rz3 和 Rz4。R1、R2、R3 和 R4 彼此相同或不同，各自代表氢原子、卤素原子、C1-6 烷基、C1-6 烷氧基、C3-7 环烷基等。
• CARBOXYLIC ACIDS
  申请人：Eisai Co., Ltd.

  公开号：EP1375484A1

  公开（公告）日：2004-01-02

  The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them. In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R1, R2, R3, R4, R5, R6, R7 and R8 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III): (wherein Z represents a group represented by the formula (IV): (wherein R9, R10, R11 and R12 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group)); m is 0 or 1; and n is 0 or 1.

  本发明提供了一种可用作胰岛素增敏剂的新型羧酸衍生物、其盐或其水合物，以及以该衍生物为有效成分的药物。更具体地说，它提供了一种由式（I）代表的羧酸化合物、其盐或它们的水合物。 式中，Ar代表6-至14元芳香环基，该环基可具有至少一个取代基；R1、R2、R3、R4、R5、R6、R7和R8彼此相同或不同，且各自代表氢原子、卤素原子、羟基、C1-6烷基或C1-6烷氧基；X代表氧原子或亚甲基；Y代表由式(II)或(III)代表的基团： (其中 Z 代表由式（IV）代表的基团： (其中 R9、R10、R11 和 R12 彼此相同或不同，且各自代表氢原子、卤素原子、羟基、C1-6 烷基或 C1-6 烷氧基））；m 为 0 或 1；n 为 0 或 1。
• US7253178B2
  申请人：——

  公开号：US7253178B2

  公开（公告）日：2007-08-07