5-amino-N-(1,2-diphenylethyl)-(S)-2-(N'-(4-methyl-1-naphthalenesulfonyl)amino)pentanamide | 849947-98-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-amino-N-(1,2-diphenylethyl)-(S)-2-(N'-(4-methyl-1-naphthalenesulfonyl)amino)pentanamide
• 英文别名: (2S)-5-amino-N-(1,2-diphenylethyl)-2-[(4-methylnaphthalen-1-yl)sulfonylamino]pentanamide
• CAS: 849947-98-4
• 化学式: C₃₀H₃₃N₃O₃S
• 分子量: 515.676
• InChiKey: PRADZSLQSXYLIE-MBMZGMDYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  37
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  110
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• SOMATOSTATIN RECEPTOR 1 AND/OR 4 SELECTIVE AGONISTS AND ANTAGONISTS
  申请人：Wurster, Siegfried

  公开号：EP1675824B1

  公开（公告）日：2010-09-29
• Somatostatin receptor 1 and/or 4 selective agonists and antagonists
  申请人：Tomperi Jussi

  公开号：US20070129422A1

  公开（公告）日：2007-06-07

  The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein R1, R2, R3, A, B, D, Q, k and n are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and selectivity for the somatostatin receptor subtypes SSTR1 and/or SSTR4 and can be used for the treatment or diagnosis of diseases or conditions wherein an interaction with SSTR1 and/or SSTR4 is indicated to be useful.
• Somatostatin Receptor 1 and/or 4 Selective Agonists and Antagonists
  申请人：Tomperi Jussi

  公开号：US20100004339A1

  公开（公告）日：2010-01-07

  The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein R1, R2, R3, A, B, D, Q, k and n are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and selectivity for the somatostatin receptor subtypes SSTR1 and/or SSTR4 and can be used for the treatment or diagnosis of diseases or conditions wherein an interaction with SSTR1 and/or SSTR4 is indicated to be useful.
• US7741362B2
  申请人：——

  公开号：US7741362B2

  公开（公告）日：2010-06-22