N-[3-chloro-2-[(2-napthylsulfanyl)methyl]-1-(4-{[(phenylsulfonyl)amino]carbonyl}benzyl)-1H-indol-5-yl]cyclopentanecarboxamide | 241493-00-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[3-chloro-2-[(2-napthylsulfanyl)methyl]-1-(4-{[(phenylsulfonyl)amino]carbonyl}benzyl)-1H-indol-5-yl]cyclopentanecarboxamide
• 英文别名: N-[3-chloro-2-[(2-naphthylsulfanyl)methyl]-1-(4-{[(phenylsulfonyl)amino]carbonyl}benzyl)-1H-indol-5-yl]cyclopentanecarboxamide；N-(benzenesulfonyl)-4-[[3-chloro-5-(cyclopentanecarbonylamino)-2-(naphthalen-2-ylsulfanylmethyl)indol-1-yl]methyl]benzamide
• CAS: 241493-00-5
• 化学式: C₃₉H₃₄ClN₃O₄S₂
• 分子量: 708.302
• InChiKey: MQIWNGNYIAGSCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  49
• 可旋转键数：
  10
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  131
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-({3-chloro-5-[(cyclopentylcarbonyl)amino]-2-[(2-naphthylsulfanyl)methyl]-1H-indol-1-yl}methyl)benzoic acid 以40%的产率得到N-[3-chloro-2-[(2-napthylsulfanyl)methyl]-1-(4-{[(phenylsulfonyl)amino]carbonyl}benzyl)-1H-indol-5-yl]cyclopentanecarboxamide
  参考文献：
  名称：

  Inhibitors of phospholipase enzymes

  摘要：

  本发明披露了一种新型化合物，可抑制哺乳动物中磷脂酶酶活性，特别是细胞质磷脂酶A2。本发明还披露了包括这些化合物的制药组合物和使用这些组合物的治疗方法。

  公开号：

  US20030153751A1

文献信息

• INHIBITORS OF PHOSPHOLIPASE ENZYMES
  申请人：GENETICS INSTITUTE, INC.

  公开号：EP1056719A2

  公开（公告）日：2000-12-06
• US6828344B1
  申请人：——

  公开号：US6828344B1

  公开（公告）日：2004-12-07
• US6916841B2
  申请人：——

  公开号：US6916841B2

  公开（公告）日：2005-07-12
• [EN] INHIBITORS OF PHOSPHOLIPASE ENZYMES<br/>[FR] INHIBITEURS D'ENZYMES PHOSPHOLIPASES
  申请人：——

  公开号：WO1999043651A2

  公开（公告）日：1999-09-02

  [EN] Novel compounds are disclosed which inhibit the activity of phospholipase enzymes, particularly cytosolic phospholipase A2. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.
  [FR] L'invention concerne de nouveaux composés qui inhibent l'activité d'enzymes phospholipases, en particulier la phospholipase A2 cytosolique. On décrit des compositions pharmaceutiques contenant lesdits composés et des méthodes de traitement mettant en oeuvre lesdites compositions.
• [EN] TRIARYL BORANE CATALYSTS AND METHOD FOR SELECTIVE HYDROSILYLATION OF ESTERS AND LACTONES USING SAID CATALYSTS<br/>[FR] CATALYSEURS AU TRIARYLBORANE ET PROCÉDÉ D'HYDROSILYLATION SÉLECTIVE D'ESTERS ET DE LACTONES À L'AIDE DESDITS CATALYSEURS
  申请人：[en]ALDEXCHEM KFT.

  公开号：WO2022129966A1

  公开（公告）日：2022-06-23

  The present invention relates to a catalytic process for the partial reduction of esters or lactones to silyl acetals, which upon hydrolysis give aldehydes, using silanes as reducing agents, preferably triethylsilane (TESH) or 1,1,3,3-tetramethyldisiloxane (TMDS), in the presence of novel triaryl borane type catalysts. More specifically, the present invention relates to novel triaryl borane type catalyst compounds of formula (I) which can be applied for the partial reduction of an ester or lactone to a silyl acetal. In the formula R1, R'1, R5, R'5and R6are groups having small steric demand and R10is a group having large steric demand. The invention also relates to a method for the preparation of aldehydes or lactols wherein said method comprises the following steps: i) an ester or lactone is reacted with a silane in the presence of a compound of formula (I) to obtain a silyl acetal; ii) the obtained silyl acetal is hydrolysed with acidic or fluoride containing reagent to form an aldehyde or lactol; iii) optionally, the resulting aldehyde or lactol is separated and purified.