t-butyl 4-[3-(2-butynyl)-4-chloro-3H-imidazo[4,5-c]pyridin-2-yl]piperazine-1-carboxylate | 635723-26-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: t-butyl 4-[3-(2-butynyl)-4-chloro-3H-imidazo[4,5-c]pyridin-2-yl]piperazine-1-carboxylate
• 英文别名: Tert-butyl 4-(3-but-2-ynyl-4-chloroimidazo[4,5-c]pyridin-2-yl)piperazine-1-carboxylate
• CAS: 635723-26-1
• 化学式: C₁₉H₂₄ClN₅O₂
• 分子量: 389.885
• InChiKey: HNEUETCDTSHRIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  63.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  acetonitrile-water 、 t-butyl 4-[3-(2-butynyl)-4-chloro-3H-imidazo[4,5-c]pyridin-2-yl]piperazine-1-carboxylate 、 碘甲烷 在 sodium acetate 、 potassium carbonate 作用下， 以 二甲基亚砜 、 三氟乙酸 为溶剂， 生成 3-(2-Butynyl)-5-methyl-2-(piperazin-1-yl)-3,5-dihydroimidazo[4,5-c]pyridin-4-one trifluoroacetate
  参考文献：
  名称：

  Condensed imidazole derivatives

  摘要：

  本发明涉及以下公式所代表的化合物，或其盐或水合物 其中， T 1 代表一个含有一个或两个氮原子的4-至12-成员杂环基团，在环中是单环或双环结构，可能具有一个或多个取代基; X代表一个C 1-6 烷基基团，可能具有一个或多个取代基，或类似物; Z 1 和Z 2 各自独立地代表一个氮原子或由公式—CR 2 —所代表的基团; R 1 和R 2 独立地代表氢原子，一个C 1-6 烷基基团，可能具有一个或多个取代基，或一个C 1-6 烷氧基基团，可能具有一个或多个取代基，或类似物。 这些是表现出优异DPPIV抑制活性的新颖化合物。

  公开号：

  US20040116328A1

文献信息

• Bicyclic modulators of androgen receptor function
  申请人：——

  公开号：US20040019063A1

  公开（公告）日：2004-01-29

  The invention provides for a pharmaceutical composition capable of modulating the androgen receptor comprising a compound of formula I 1 wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.

  该发明提供了一种能够调节雄激素受体的药物组合物，包括公式I1中的化合物，其中取代基如本文所述。进一步提供了使用这些化合物治疗核激素受体相关疾病的方法，例如与年龄相关的疾病，如肌少症。还提供了含有这些化合物的药物组合物和制备该发明中一些化合物的方法。
• Novel condensed imidazole derivatives
  申请人：Yoshikawa Seiji

  公开号：US20060100199A1

  公开（公告）日：2006-05-11

  The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T 1 represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substituents; X represents a C 1-6 alkyl group which may have one or more substituents, or such; Z 1 and Z 2 each independently represent a nitrogen atom or a group represented by the formula —CR 2 —; R 1 and R 2 independently represent a hydrogen atom, a C 1-6 alkyl group which may have one or more substituents, or a C 1-6 alkoxy group which may have one or more substituents, or such. These are novel compounds that exhibit an excellent

  本发明涉及以下式子所表示的化合物、盐或水合物：其中，T1代表一个含有一个或两个氮原子的4-至12元杂环基团，它是一个单环或双环结构，可能有一个或多个取代基；X代表一个C1-6烷基基团，它可能有一个或多个取代基，或者如此；Z1和Z2各自独立地代表一个氮原子或者由公式—CR2—所表示的基团；R1和R2各自独立地代表一个氢原子，一个C1-6烷基基团，它可能有一个或多个取代基，或者一个C1-6烷氧基基团，它可能有一个或多个取代基，或者如此。这些是新颖的化合物，具有优异的性能。
• CONDENSED IMIDAZOLE DERIVATIVES
  申请人：Yoshikawa Seiji

  公开号：US20090018331A1

  公开（公告）日：2009-01-15

  The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T 1 represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substituents; X represents a C 1-6 alkyl group which may have one or more substituents, or such; Z 1 and Z 2 each independently represent a nitrogen atom or a group represented by the formula —CR 2 —; R 1 and R 2 independently represent a hydrogen atom, a C 1-6 alkyl group which may have one or more substituents, or a C 1-6 alkoxy group which may have one or more substituents, or such. These are novel compounds that exhibit an excellent DPPIV-inhibiting activity.

  本发明涉及下式所示的化合物、盐或水合物： 其中， T1表示一个4-到12成员的杂环基团，在环中含有一个或两个氮原子，是单环或双环结构，可以有一个或多个取代基； X表示一个C1-6烷基基团，可以有一个或多个取代基； Z1和Z2各自独立地表示一个氮原子或由公式—CR2—表示的基团； R1和R2各自独立地表示氢原子、一个C1-6烷基基团，可以有一个或多个取代基，或一个C1-6烷氧基基团，可以有一个或多个取代基。 这些是具有出色的DPPIV抑制活性的新型化合物。
• BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION
  申请人：Sun Chong-Qing

  公开号：US20080108649A1

  公开（公告）日：2008-05-08

  There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.

  提供了按公式I描述的化合物，其中取代基如此描述。还提供了使用这种化合物治疗核激素受体相关疾病的方法，例如与年龄相关的疾病，例如肌肉萎缩症。还提供了含有这种化合物的药物组合物和制备本发明部分化合物的方法。还揭示了其他实施例。
• NOVEL FUSED IMIDAZOLE DERIVATIVE
  申请人：Eisai Co., Ltd.

  公开号：EP1514552A1

  公开（公告）日：2005-03-16

  The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T1 represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substituents; X represents a C1-6 alkyl group which may have one or more substituents, or such; Z1 and Z2 each independently represent a nitrogen atom or a group represented by the formula -CR2-; R1 and R2 independently represent a hydrogen atom, a C1-6 alkyl group which may have one or more substituents, or a C1-6 alkoxy group which may have one or more substituents, or such. These are novel compounds that exhibit an excellent DPPIV-inhibiting activity.

  本发明涉及下式所代表的化合物或其盐类或水合物 其中 T1 代表环中含有一个或两个氮原子的 4 至 12 元杂环基团，其为单环或双环结构，可具有一个或多个取代基； X 代表可带有一个或多个取代基的 C1-6 烷基，或此类； Z1和Z2各自独立地代表一个氮原子或一个由式-CR2-代表的基团； R1和R2各自独立地代表氢原子、C1-6烷基（可带有一个或多个取代基）或C1-6烷氧基（可带有一个或多个取代基）或此类基团。 这些新型化合物具有优异的 DPPIV 抑制活性。