tert-butyl 3-acetyl-1H-1-indazolecarboxylate | 473416-42-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: tert-butyl 3-acetyl-1H-1-indazolecarboxylate
• 英文别名: 1h-Indazole-1-carboxylic acid,3-acetyl-,1,1-dimethylethyl ester；tert-butyl 3-acetylindazole-1-carboxylate
• CAS: 473416-42-1
• 化学式: C₁₄H₁₆N₂O₃
• 分子量: 260.293
• InChiKey: RAVXLWBBLPGPHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  61.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT
  申请人：Sim Tae Bo

  公开号：US20120130069A1

  公开（公告）日：2012-05-24

  Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.

  本发明揭示了新型吲唑衍生物，其化学式如下所示（Chemical Formula 1），或其药学上可接受的盐、水合物或溶剂化合物，以及包含其作为活性成分的用于预防或治疗增殖性疾病的药物组合物。这些新型吲唑衍生物具有对蛋白激酶（如b-raf、KDR、Fms、Tie2、SAPK2a和Ret）具有强大的抑制作用，诱导由异常细胞增殖引起的疾病，可用于预防或治疗由异常细胞增殖引起的疾病。
• Novel 1H-indazole compounds
  申请人：Oinuma Hitoshi

  公开号：US20050282880A1

  公开（公告）日：2005-12-22

  The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R 1 is a C 6 -C 14 aromatic cyclic hydrocarbon group etc.; R 2 , R 4 and R 5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C 1 -C 6 alkylene group etc.; X is a single bond, or a group represented by —CO—NH— or —NH—CO—, etc.; and Y is a C 3 -C 8 cycloalkyl group, a C 6 -C 14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.

  本发明提供了一种新型的1H-吲唑化合物，具有出色的JNK抑制作用。更具体地说，提供了以下公式所表示的化合物，其盐或水合物。其中，R1是C6-C14芳香环烃基等；R2、R4和R5各自独立地表示氢原子、卤原子、氰基等；L是单键或C1-C6烷基等；X是单键或由—CO—NH—或—NH—CO—等表示的基团；Y是C3-C8环烷基、C6-C14芳香环烃基或5-至14成员芳香杂环基等。
• Novel 1h-indazole compound
  申请人：——

  公开号：US20040127538A1

  公开（公告）日：2004-07-01

  The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. 1 Wherein R 1 is a C 6 -C 14 aromatic cyclic hydrocarbon group etc.; R 2 , R 4 and R 5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C 1 -C 6 alkylene group etc.; X is a single bond, or a group represented by —CO—NH— or —NH—CO—, etc.; and Y is a C 3 -C 8 cycloalkyl group, a C 6 -C 14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.

  本发明提供了一种具有出色的JNK抑制作用的新型1H-吲唑化合物。更具体地，它提供了以下式子所表示的化合物、其盐或水合物。其中，R1为C6-C14芳香环烃基等；R2、R4和R5各自独立地表示氢原子、卤素原子、氰基等；L为单键或C1-C6烷基等；X为单键或由—CO—NH—或—NH—CO—等表示的基团；Y为C3-C8环烷基、C6-C14芳香环烃基或5-至14-环芳杂环基等。
• NOVEL 1H-INDAZOLE COMPOUND
  申请人：Eisai Co., Ltd.

  公开号：EP1380576A1

  公开（公告）日：2004-01-14

  The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by -CO-NH- or -NH-CO-, etc.; and Y is a C3-C8 cycloalkyl group, a C6-C14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.

  本发明提供了一种新型 1H-indazole 化合物，它具有出色的 JNK 抑制作用。更具体地说，它提供了由下式代表的化合物、其盐或它们的水合物。 其中，R1 是 C6-C14 芳环烃基等；R2、R4 和 R5 各自独立地代表氢原子、卤素原子、氰基等；L 是单键或 C1-C6 亚烷基等；X 是单键或由 -CO-NH- 或 -NH-CO- 等代表的基团；Y 是 C3-C8 环烷基、C6-C14 芳环烃基或 5 至 14 元芳香杂环基等。
• 1H-INDAZOLE COMPOUNDS INHIBITING JNK
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1380576B1

  公开（公告）日：2009-11-25