2-Methyl-3H-pyrrolo[2,3-B]pyridine | 91785-56-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 2-Methyl-3H-pyrrolo[2,3-B]pyridine
• CAS: 91785-56-7
• 化学式: C₈H₈N₂
• 分子量: 132.16
• InChiKey: ZZUGRLSUBKFUPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  25.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• 4-(Benzoimidazol-2-yl)-thiazole Compounds and Related Aza Derivatives
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：US20140371204A1

  公开（公告）日：2014-12-18

  The invention relates to compounds of Formula (I) wherein ring A, X, (R 1 ) n , R 2 , R 3 , R 4 , R 4′ , R 5 , n, and p are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.

  本发明涉及式(I)化合物，其中环A、X、(R1)n、R2、R3、R4、R4′、R5、n和p如描述中所述；涉及药用可接受的盐，以及将此类化合物用作药物，尤其是用作CXCR3受体的调节剂。
• Organic Compounds as Smo Inhibitors
  申请人：HE Feng

  公开号：US20100041663A1

  公开（公告）日：2010-02-18

  The present invention relates generally to novel compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders. The present invention includes novel compounds, novel compositions, methods of their use and methods of their manufacture, where such compounds are generally pharmacologically useful as agents in therapies whose mechanism of action involve methods of inhibiting tumorigenesis, tumor growth and tumor survival using agents that inhibit the Hedgehog and Smo signaling pathway.

  本发明一般涉及与Hedgehog通路相关的病理诊断和治疗的新化合物，包括但不限于肿瘤形成、癌症、肿瘤和非恶性过度增殖性疾病。本发明包括新化合物、新组合物、它们的使用方法和制备方法，这些化合物通常在药理学上作为治疗剂是有用的，其作用机制涉及通过抑制Hedgehog和Smo信号通路的方法来抑制肿瘤发生、肿瘤生长和肿瘤存活。
• AZACYANINE DYES AND USE THEREOF
  申请人：Ecole Polytechnique Fédérale de Lausanne (EPFL)

  公开号：US20180079906A1

  公开（公告）日：2018-03-22

  The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging.

  该应用程序提供荧光染料，这些染料是氰染料，它们在吲哚啉环中和/或连接它们的亚甲链中包含额外的氮杂基。描述了用于共轭的对称和非对称化学反应性氮杂氰染料，以及它们的生物共轭物用于体外和体内分析和荧光成像。
• 1,2,3-TRIAZOLE-BASED PEPTIDOMIMETIC INTEGRIN INHIBITORS FOR THE DIAGNOSIS AND THERAPY OF TUMORS
  申请人：Guarna Antonio

  公开号：US20130040964A1

  公开（公告）日：2013-02-14

  The present invention refers to the field of chemical compounds bearing a 1,2,3-triazole ring of formula (I) and possessing guanidino and carboxylic groups or their isosteres, their preparation by Cu-catalyzed “click-chemistry”, and medical-diagnostic use in pathologies where angiogenesis is altered, for example pathologic conditions of tumor origin, tumor metastasis, osteoporosis, and rheumatoid arthritis.

  本发明涉及具有化学化合物的领域，其具有1,2,3-三唑环的结构（I）并且具有胍基和羧基或其同分异构体，通过铜催化的“点击化学”方法制备这些化合物，并在血管生成异常的病理学中进行医学诊断使用，例如肿瘤起源的病理性状况、肿瘤转移、骨质疏松症和类风湿性关节炎。
• POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, AND OPTICALLY ANISOTROPIC PRODUCT
  申请人：ZEON CORPORATION

  公开号：US20160257659A1

  公开（公告）日：2016-09-08

  This invention provides a polymerizable compound represented by formula (I), a polymerizable composition containing the polymerizable compound and a polymerization initiator, a polymer produced by polymerizing the polymerizable compound or the polymerizable composition, and an optically anisotropic product comprising the polymer as a constituent material. In formula (1), Y 1 to Y 9 represent —O—, —S—, —O—C(═O)—, —C(═O)—O— or the like, G 1 and G 2 represent a divalent linear aliphatic group having 1 to 20 carbon atoms or the like, Z 1 to Z 3 represent an alkenyl group having 2 to 10 carbon atoms or the like, A x represents a group represented by a formula (II), wherein X represents an oxygen atom, a sulfur atom or the like, D represents an alkylene group having 1 to 20 carbon atoms or the like, A 1 represents a trivalent aromatic group or the like, A 2 and A 3 represent a divalent alicyclic hydrocarbon group having 3 to 30 carbon atoms or the like, A 4 and A 5 represent a divalent aromatic group having 4 to 30 carbon atoms or the like, Q 1 represents an alkyl group having 1 to 6 carbon atoms or the like, and m and n are 0 or 1.

  这项发明提供了一种可聚合化合物，其表示为式(I)，一种含有该可聚合化合物和聚合引发剂的可聚合组合物，通过聚合该可聚合化合物或可聚合组合物而制备的聚合物，以及作为构成材料的聚合物的光学各向异性产品。在式(1)中，Y1至Y9代表—O—、—S—、—O—C(═O)—、—C(═O)—O—或类似物，G1和G2代表具有1至20个碳原子的双价直链脂肪族基或类似物，Z1至Z3代表具有2至10个碳原子的烯基基团或类似物，Ax代表由式(II)表示的基团，其中X代表氧原子、硫原子或类似物，D代表具有1至20个碳原子的烷基基团或类似物，A1代表三价芳香族基或类似物，A2和A3代表具有3至30个碳原子的双价脂环烃基或类似物，A4和A5代表具有4至30个碳原子的双价芳香族基或类似物，Q1代表具有1至6个碳原子的烷基基团或类似物，m和n为0或1。