2-((11bS)-3H-binaphtho[2,1-c:1',2'-e]phosphepin-4(5H)-yl)ethanamine | 1092064-06-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-((11bS)-3H-binaphtho[2,1-c:1',2'-e]phosphepin-4(5H)-yl)ethanamine
• 英文别名: 2-[(11bS)-3,5-Dihydro-4H-dinaphtho[2,1-c:1',2'-e]phosphepin-4-yl]ethyl]amine；2-(13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaen-13-yl)ethanamine
• CAS: 1092064-06-6
• 化学式: C₂₄H₂₂NP
• 分子量: 355.419
• InChiKey: PXDLCEFIOZLJLW-UHFFFAOYSA-N

物化性质

• 熔点：
  64-70 °C
• 沸点：
  600.2±54.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-((11bS)-3H-binaphtho[2,1-c:1',2'-e]phosphepin-4(5H)-yl)ethanamine 在 tetrafluoroboric acid 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.5h， 以71%的产率得到2-((11bS)-3H-binaphtho[2,1-c:1',2'-e]phosphepin-4(5H)-yl)ethanammonium tetrafluoroborate
  参考文献：
  名称：

  METHOD FOR PREPARING A METAL CATALYST

  摘要：

  本公开涉及一种制备金属催化剂的方法，该方法包括至少一种通过至少一个磷（P）原子和至少一个氮（N）原子配位到金属的配体，所述方法包括在碱的存在下，将金属前体配合物与氨基膦、二氨基膦、氨基双膦或二氨基双膦的酸和盐反应。

  公开号：

  US20120046479A1
• 作为产物：
  描述：

  tert-butyl 2-((S)-3H-dinaphtho[2,1-c:1',2'-e]phosphepine-4(5H)-yl)ethylcarbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以88%的产率得到2-((11bS)-3H-binaphtho[2,1-c:1',2'-e]phosphepin-4(5H)-yl)ethanamine
  参考文献：
  名称：

  Synthesis of Chiral Aminophosphines from Chiral Aminoalcohols via Cyclic Sulfamidates

  摘要：

  Protic aminophosphines with multiple chiral centers were synthesized in good yields and high purity by the nucleophilic ring-opening of N-protected cyclic sulfamidates with metal phosphides, followed by hydrolysis and deprotection. This synthetic approach is clean, scalable, and high yielding. The method provides an efficient alternative route for the synthesis of chiral aminophosphines.

  DOI：

  10.1021/jo902302c

文献信息

• Rhodium-P,O-bidentate coordinated ureaphosphine ligands for asymmetric hydrogenation reactions
  作者：Jurjen Meeuwissen、Remko J. Detz、Albertus J. Sandee、Bas de Bruin、Joost N. H. Reek

  DOI：10.1039/b926043a

  日期：——

  We present new ureaphosphine ligands that coordinate in a P,O-bidentate fashion to rhodium(I). The ureaphosphine-Rh(I)-complexes were effectively used in the asymmetric hydrogenation of cyclic enamides giving high conversions and enantioselectivity.

  我们提出新的 脲膦以P，O-二齿形式与铑（I）配位的配体。这脲膦-Rh（I）-配合物可有效用于环状酰胺的不对称氢化，从而提供高转化率和对映选择性。
• PRACTICAL METHOD FOR REDUCING ESTERS OR LACTONES
  申请人：Tokyo Institute of Technology

  公开号：EP2298723A1

  公开（公告）日：2011-03-23

  Esters and lactones can be respectively reduced to alcohols and diols in the presence of the Group 8 (VIII) transition metal complex, base and hydrogen gas (H2). An extremely practical reduction method can be provided by preferable combinations of the Group 8 (VIII) transition metal complex, the base, a used amount of the base, a pressure of hydrogen gas and a reaction temperature. This method is used in place of hydride reduction and is a useful method by which design of highly active catalysts can be relatively easily made while a high productivity can be expected.

  在第 8 (VIII) 族过渡金属络合物、碱和氢气 (H2) 的存在下，酯和内酯可分别还原成醇和二元醇。8 (VIII)族过渡金属络合物、碱、碱的用量、氢气的压力和反应温度的最佳组合可以提供一种极为实用的还原方法。这种方法可代替氢化物还原法，是一种有用的方法，可以相对容易地设计出高活性催化剂，同时可望获得较高的生产率。
• [EN] METHOD FOR THE PREPARATION OF AMINOPHOSPHINE LIGANDS AND THEIR USE IN METAL CATALYSTS<br/>[FR] PROCÉDÉ D'OBTENTION DE LIGANDS DE TYPE AMINOPHOSPHINE ET LEUR UTILISATION COMME CATALYSEURS MÉTALLIQUES
  申请人：KANATA CHEMICAL TECHNOLOGIES I

  公开号：WO2008148202A8

  公开（公告）日：2009-07-23
• METHOD FOR THE PREPARATION OF AMINOPHOSPHINE LIGANDS AND THEIR USE IN METAL CATALYSTS
  申请人：Abdur-Rashid Kamaluddin

  公开号：US20100204514A1

  公开（公告）日：2010-08-12

  The present application is directed to i) a method for synthesizing aminophosphine (P,N) and phosphine-aminophosphine (P,N,P) ligands, ii) the use of such ligands in the preparation of metal complexes as hydrogenation catalysts, and iii) aminophosphine (P,N) and phosphine-aminophosphine (P,N,P) ligands of various structures. In particular, the methods in i) involve reacting a protected tertiary amine of formula (I) with a metal phosphide of the formula Y—PR8R9 to afford an aminophosphine of formula (II), which can then be optionally further reacted with a phosphine of the formula (III) to afford the phosphine-aminophosphine of formula (IV).
• Practical Method for Reducing Esters or Lactones
  申请人：Ikariya Takao

  公开号：US20110092747A1

  公开（公告）日：2011-04-21

  Esters and lactones can be respectively reduced to alcohols and diols in the presence of the Group 8 (VIII) transition metal complex, base and hydrogen gas (H 2 ). An extremely practical reduction method can be provided by preferable combinations of the Group 8 (VIII) transition metal complex, the base, a used amount of the base, a pressure of hydrogen gas and a reaction temperature. This method is used in place of hydride reduction and is a useful method by which design of highly active catalysts can be relatively easily made while a high productivity can be expected.