2-(3,4-methylenedioxyphenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine | 1228115-01-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 2-(3,4-methylenedioxyphenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine
• 英文别名: 2-(1,3-Benzodioxol-5-yl)-1-methylpyrrolo[2,3-b]pyridine
• CAS: 1228115-01-2
• 化学式: C₁₅H₁₂N₂O₂
• 分子量: 252.272
• InChiKey: PWBGYJGKUHTXGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Amide derivatives and drugs
  申请人：Maruyama Yasufumi

  公开号：US20050014942A1

  公开（公告）日：2005-01-20

  The present invention provides an amide derivative represented by the following formula [1]: wherein n represents 0 or 1; X represents CR 4 or N; Y represents CR 6 or N; Z represents CR 7 or N; R 1 and R 2 may be the same or different and each represents hydrogen, optionally substituted alkyl, acyl, optionally substituted aryl, or an optionally substituted aromatic heterocyclic group; R 4 , R 5 , R 6 and R 7 may be the same or different and each represents hydrogen, halogen, hydroxy, amino, alkyl, haloalkyl, alkoxy, monoalkylamino, dialkylamino, arylalkyl, cyano, or nitro; and R 3 represents optionally substituted alkylamino, optionally substituted arylamino, or optionally substituted cyclic amino, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising them as an active ingredient. The compound of the present invention is useful as a TGF-β inhibitor.

  本发明提供了一种由以下式[1]表示的酰胺衍生物：其中n代表0或1；X代表CR4或N；Y代表CR6或N；Z代表CR7或N；R1和R2可以相同或不同，并且每个代表氢，可选择取代的烷基，酰基，可选择取代的芳基或可选择取代的芳香族杂环基；R4，R5，R6和R7可以相同或不同，并且每个代表氢，卤素，羟基，氨基，烷基，卤代烷基，烷氧基，单烷基氨基，双烷基氨基，芳基烷基，氰基或硝基；R3代表可选择取代的烷基氨基，可选择取代的芳基氨基或可选择取代的环状氨基，或其药学上可接受的盐，并且其中包括以其为活性成分的制药组合物。本发明的化合物可用作TGF-β抑制剂。
• AMIDE DERIVATIVES AND DRUGS
  申请人：Nippon Shinyaku Co., Ltd.

  公开号：EP1452525A1

  公开（公告）日：2004-09-01

  The present invention provides an amide derivative represented by the following formula [1]: wherein n represents 0 or 1; X represents CR4 or N; Y represents CR6 or N; Z represents CR7 or N; R1 and R2 may be the same or different and each represents hydrogen, optionally substituted alkyl, acyl, optionally substituted aryl, or an optionally substituted aromatic heterocyclic group; R4, R5, R6 and R7 may be the same or different and each represents hydrogen, halogen, hydroxy, amino, alkyl, haloalkyl, alkoxy, monoalkylamino, dialkylamino, arylalkyl, cyano, or nitro; and R3 represents optionally substituted alkylamino, optionally substituted arylamino, or optionally substituted cyclic amino, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising them as an active ingredient. The compound of the present invention is useful as a TGF-β inhibitor.

  本发明提供了由下式[1]表示的酰胺衍生物： 其中n代表0或1；X代表CR4或N；Y代表CR6或N；Z代表CR7或N；R1和R2可以相同或不同，各自代表氢、任选取代的烷基、酰基、任选取代的芳基或任选取代的芳杂环基团；R4、R5、R6 和 R7 可以相同或不同，各自代表氢、卤素、羟基、氨基、烷基、卤代烷基、烷氧基、单烷基氨基、二烷基氨基、芳基烷基、氰基或硝基；以及 R3 代表任选取代的烷基氨基、任选取代的芳基氨基或任选取代的环氨基，或其药学上可接受的盐，以及包含它们作为活性成分的药物组合物。 本发明的化合物可用作 TGF-β 抑制剂。