2-ethyl-N-[(R)-1-(2-naphthyl)ethyl]benzamide | 1093070-12-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-ethyl-N-[(R)-1-(2-naphthyl)ethyl]benzamide
• 英文别名: 2-Ethyl-N-(1R-naphthalen-2-yl-ethyl)-benzamide；2-ethyl-N-[(1R)-1-naphthalen-2-ylethyl]benzamide
• CAS: 1093070-12-2
• 化学式: C₂₁H₂₁NO
• 分子量: 303.404
• InChiKey: GTAGUQHFAFXROX-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• COMPOUNDS AND METHODS FOR TREATING RESPIRATORY DISEASES
  申请人：Ghosh Arun K.

  公开号：US20110269834A1

  公开（公告）日：2011-11-03

  Described herein are compounds and compositions, and methods for using the compounds and compositions, for treating respiratory diseases and illness, such as severe acute respiratory syndrome (SARS).

  本文描述了化合物和组合物，以及使用这些化合物和组合物治疗呼吸道疾病和疾病，如严重急性呼吸综合征（SARS）的方法。
• [EN] COMPOSITIONS AND METHODS FOR TREATMENT OF SARS-COV-2<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE SARS-COV-2
  申请人：UNIV GEORGIA

  公开号：WO2021189046A1

  公开（公告）日：2021-09-23

  Compositions and method of reducing activity of a SARS-CoV-2 PLpro are provided. The methods typically include contacting a SARS-CoV-2 PLpro with an effective amount of a PLpro inhibitor compound to reduce the activity of the a SARS-CoV-2 PLpro. In some embodiments, the activity that is reduced includes or consists of cleavage of a SARS-CoV-2 polypeptide, deubiquitination, deISGylation, or a combination thereof. In some embodiments, the activity that is reduced includes or consists of suppression of a host innate immune response. In some embodiments, the contacting occurs in a subject in vivo. The subject can have a SARS-CoV-2 infection. Thus, methods of treating a SARS-CoV-2 infection are also provided.