1-Methyl-2-dimethylamino-naphthalin | 5672-92-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Methyl-2-dimethylamino-naphthalin
• 英文别名: N,N,1-trimethylnaphthalen-2-amine
• CAS: 5672-92-4
• 化学式: C₁₃H₁₅N
• 分子量: 185.269
• InChiKey: JLQIXDQZCOPEPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• POLYMER COMPOUND AND POLYMER LIGHT EMITTING DEVICE USING THE SAME
  申请人：Kobayashi Satoshi

  公开号：US20100286360A1

  公开（公告）日：2010-11-11

  A polymer compound comprising a residue of a compound of the following formula (1): (wherein, a ring C 1 , ring C 2 and ring C 3 represent each independently an aromatic hydrocarbon ring or hetero ring. A 1 represents a di-valent group containing one or more atoms selected from a boron atom, carbon atom, nitrogen atom, oxygen atom, phosphorus atom, sulfur atom and selenium atom. R 1 represents an alkyl group, alkoxy group, alkylthio group, aryl group, aryloxy group, arylthio group, arylalkyl group, arylalkyloxy group, arylalkylthio group, alkenyl group, alkynyl group, di-substituted amino group, tri-substituted silyl group, acyl group, acyloxy group, imine residue, amide group, acid imide group, mono-valent heterocyclic group, substituted carboxyl group, heteroaryloxy group or heteroarylthio group, or is connected to an atom adjacent to an atom on the ring C 3 to which R 1 is connected, to form a ring.).
• [EN] PRMT5 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE PRMT5 ET LEURS UTILISATIONS
  申请人：EPIZYME INC

  公开号：WO2015200680A2

  公开（公告）日：2015-12-30

  Described herein are compounds of Formula (I)-(XIII), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.