| 1191890-62-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1191890-62-6
• 化学式: C₂₅H₂₃N₃O₄
• 分子量: 429.475
• InChiKey: HDINIQUQFMRVFT-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 lithium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 14.0h， 以95%的产率得到
  参考文献：
  名称：

  Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase

  摘要：

  A series of 4H-pyrazolo[1,5-a]pyrimidin-7-one derivatives was synthesized and evaluated for inhibitory activity against HCV NS5B RNA-dependent RNA polymerase. A number of these compounds exhibited potent activity in enzymatic assay. The synthesis and structure-activity relationship are also described. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.124
• 作为产物：
  描述：

  5-氨基-吡唑-3-甲酸乙酯 、 在 对甲苯磺酸 作用下， 以 氯苯 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase

  摘要：

  A series of 4H-pyrazolo[1,5-a]pyrimidin-7-one derivatives was synthesized and evaluated for inhibitory activity against HCV NS5B RNA-dependent RNA polymerase. A number of these compounds exhibited potent activity in enzymatic assay. The synthesis and structure-activity relationship are also described. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.124