2,3,5,4‘-tetrahydroxystilbene | 97612-27-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2,3,5,4‘-tetrahydroxystilbene
• 英文别名: 2,3,5,4′-tetrahydroxystilbene；6-[2-(4-Hydroxyphenyl)ethenyl]benzene-1,2,4-triol
• CAS: 97612-27-6
• 化学式: C₁₄H₁₂O₄
• 分子量: 244.247
• InChiKey: WREAQMXXCUARJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,3,5,4'‐tetrahydroxystilbene‐2‐O‐β‐D‐glucoside 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 14.0h， 以32%的产率得到2,3,5,4‘-tetrahydroxystilbene
  参考文献：
  名称：

  2,3,5,4'-四羟基芪降低乳腺肿瘤的耐药性以显示协同化疗效果。

  摘要：

  由于癌细胞对抗癌药物产生多药耐药性，化疗药物在乳腺癌中的疗效有限。在这项研究中，我们通过修饰 2,3,5,4'-四羟基芪-2-O-β-D-葡萄糖苷 (THSG) 开发了一种新型衍生物 2,3,5,4'-四羟基芪 (TG1)。斑马鱼体内胚胎试验表明，TG1 具有低毒性。DOX或DTX与TG1在MCF-7/Adr中的等毒组合降低了DOX或DTX的IC50，并且组合指数（CI）在1:3摩尔比的DTX:TG1和1:5摩尔比显示出强烈的协同效应DOX：TG1的比率。此外，荧光图像证实了在 MCF-7/Adr 中与 TG1 结合时 DOX 的细胞摄取。Western印迹分析表明用TG1处理MCF-7/Adr后p-糖蛋白(P-gp)的下调。综上所述，DTX或DOX与TG1的联合治疗通过抑制p-糖蛋白外排泵增加药物疗效。这些结果表明，TG1 可能对乳腺癌患者有潜在的用途，尤其是那些具有多药耐药性的患者。

  DOI：

  10.1371/journal.pone.0260533

文献信息

• USE OF FOTI TO ENHANCE STEM CELL MOBILIZATION AND PROLIFERATION
  申请人：Stemtech International Inc.

  公开号：EP2779834A1

  公开（公告）日：2014-09-24
• COMPOSITIONS AND METHODS FOR ENHANCING MOBILIZATION AND PROLIFERATION OF BLASTOMERE-LIKE STEM CELLS
  申请人：Stemtech International, Inc.

  公开号：EP2872623A1

  公开（公告）日：2015-05-20
• [EN] USE OF FOTI TO ENHANCE STEM CELL MOBILIZATION AND PROLIFERATION<br/>[FR] UTILISATION DE FO-TI POUR AMÉLIORER LA MOBILISATION ET LA PROLIFÉRATION DE CELLULES SOUCHES
  申请人：STEMTECH INTERNATIONAL INC

  公开号：WO2013074801A1

  公开（公告）日：2013-05-23

  The present invention provides a method of using Polygonum multiflorum or extracts thereof to enhance stem cell mobilization in a subject, including hematopoietic stem cells (HSCs) and bone marrow stem cells (BMSCs). In one embodiment, a blended composition of plant parts, fruits, mushrooms, microorganisms, maternal fluids, and extracts thereof are used to promote mobilization of stem cells, resulting in migration of the stem cells to specific sties of maintenance and repair within tissues and/or organs. Increased circulation of HSCs and/or BMSCs and migration towards sites of maintenance promotes the natural regeneration mechanisms in the body.
• [EN] COMPOSITIONS AND METHODS FOR ENHANCING MOBILIZATION AND PROLIFERATION OF BLASTOMERE-LIKE STEM CELLS<br/>[FR] COMPOSITIONS ET PROCÉDÉS PERMETTANT D'ACCROÎTRE LA MOBILISATION ET LA PROLIFÉRATION DES CELLULES SOUCHES SIMILAIRES AU BLASTOMÈRE
  申请人：STEMTECH INTERNATIONAL INC

  公开号：WO2014011752A1

  公开（公告）日：2014-01-16

  The present invention provides a method of using mobilization agents to enhance stem cell trafficking in a subject, including very small embryonic-like (VSEL) stem cells. In one embodiment, a blended composition of algae, fruits, mushrooms, microorganisms, maternal fluids, and extracts thereof are used to promote trafficking of stem cells, resulting in migration of the stem cells to specific sites of maintenance and repair within tissues and/or organs.
• [EN] METHODS FOR TREATMENT OF HAIR GRAYING<br/>[FR] PROCÉDÉS POUR LE TRAITEMENT DE GRISONNEMENT DE CHEVEUX
  申请人：STEMTECH INTERNATIONAL INC

  公开号：WO2015081273A1

  公开（公告）日：2015-06-04

  The invention relates to methods for treating hair graying. More specifically, the present invention discloses new methods for reducing, stopping and/or reversing of hair graying in mammals by stimulating stem cell migration to produce or stimulate melanocytes in hair follicles. The invention further teaches a stem cell mobilizing composition for treating graying hair in a subject, comprising blue-green algae, which stimulates stem cell mobilization and growth of melanocytes in hair follicles.