tert-butyl (S)-1-((2R,4R)-4-benzyl-5-oxotetrahydrofuran-2-yl)-2-(4-(S)-hydroxyphenylmethylphenyl)ethyl carbamate | 1133960-36-7

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物
• 英文名称: tert-butyl (S)-1-((2R,4R)-4-benzyl-5-oxotetrahydrofuran-2-yl)-2-(4-(S)-hydroxyphenylmethylphenyl)ethyl carbamate
• CAS: 1133960-36-7
• 化学式: C₃₁H₃₅NO₅
• 分子量: 501.623
• InChiKey: CYDYVRHTQDNLBF-GCFVYEKYSA-N

反应信息

• 作为反应物：
  描述：

  tert-butyl (S)-1-((2R,4R)-4-benzyl-5-oxotetrahydrofuran-2-yl)-2-(4-(S)-hydroxyphenylmethylphenyl)ethyl carbamate 在 manganese(IV) oxide 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以76%的产率得到tert-butyl (S)-2-(4-benzoylphenyl)-1-((2R,4R)-4-benzyl-5-oxotetrahydrofuran-2-yl)ethyl carbamate
  参考文献：
  名称：

  Stereo-controlled synthesis of novel photoreactive γ-secretase inhibitors

  摘要：

  The stereoselective synthesis of novel photoreactive gamma-secretase inhibitors 2 and 3 has been achieved. Key steps of the strategy involve preparation of alpha-N-Boc-epoxide 8 and formation of lactone 14 in a practical and stereo-controlled fashion. Compounds 2 and 3 are potent gamma-secretase inhibitors and directly interact with presenilin-1, a catalytic subunit of gamma-secretase. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.117
• 作为产物：
  描述：

  在 氟化氢吡啶 作用下， 以 四氢呋喃 为溶剂， 以83%的产率得到tert-butyl (S)-1-((2R,4R)-4-benzyl-5-oxotetrahydrofuran-2-yl)-2-(4-(S)-hydroxyphenylmethylphenyl)ethyl carbamate
  参考文献：
  名称：

  Stereo-controlled synthesis of novel photoreactive γ-secretase inhibitors

  摘要：

  The stereoselective synthesis of novel photoreactive gamma-secretase inhibitors 2 and 3 has been achieved. Key steps of the strategy involve preparation of alpha-N-Boc-epoxide 8 and formation of lactone 14 in a practical and stereo-controlled fashion. Compounds 2 and 3 are potent gamma-secretase inhibitors and directly interact with presenilin-1, a catalytic subunit of gamma-secretase. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.117