7-Methyl-3,4-dihydro-1H-isoquinoline-2-carboxamidine | 46297-25-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 7-Methyl-3,4-dihydro-1H-isoquinoline-2-carboxamidine
• 英文别名: 7-methyl-3,4-dihydro-1H-isoquinoline-2-carboximidamide
• CAS: 46297-25-0
• 化学式: C₁₁H₁₅N₃
• 分子量: 189.26
• InChiKey: LOHJEQSRZLJPMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• AMIDINE DERIVATIVE
  申请人：Ajinomoto Co., Inc.

  公开号：EP2311810A1

  公开（公告）日：2011-04-20

  Provision of a novel amidine derivative or a pharmaceutically acceptable salt thereof having an activated blood coagulation factor X-inhibitory activity. A compound represented by the formula (I) wherein each symbol is as defined above, or a pharmaceutically acceptable salt thereof.

  提供一种具有活化凝血因子 X 抑制活性的新型脒衍生物或其药学上可接受的盐。由式（I）代表的化合物 其中各符号如上定义，或其药学上可接受的盐。
• MONOCYCLIC B-LACTAM COMPOUND FOR TREATING BACTERIAL INFECTION
  申请人：Medshine Discovery Inc.

  公开号：EP3747883A1

  公开（公告）日：2020-12-09

  Disclosed are a class of new monocyclic β-lactam compounds, an isomer thereof or pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the compounds, and the use of same in preparing drugs for treating diseases associated with bacterial infection. Specifically disclosed are the compounds as shown in formula (I') and formula (II'), isomers thereof or pharmaceutically acceptable salts thereof.

  公开了一类新的单环 β-内酰胺化合物、其异构体或其药学上可接受的盐、包含这些化合物的药物组合物，以及这些化合物在制备治疗与细菌感染有关的疾病的药物中的用途。具体公开了式(I')和式(II')所示的化合物、其异构体或其药学上可接受的盐。
• Monocyclic β-lactam compound for treating bacterial infection
  申请人：MEDSHINE DISCOVERY INC.

  公开号：US11459323B2

  公开（公告）日：2022-10-04

  Disclosed are a class of new monocyclic β-lactam compounds, an isomer thereof or pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the compounds, and the use of same in preparing drugs for treating diseases associated with bacterial infection. Specifically disclosed are the compounds as shown in formula (I′) and formula (II′), isomers thereof or pharmaceutically acceptable salts thereof.

  公开了一类新的单环β-内酰胺化合物、其异构体或其药学上可接受的盐、包含这些化合物的药物组合物，以及这些化合物在制备治疗与细菌感染有关的疾病的药物中的用途。具体公开了式(Ⅰ′)和式(Ⅱ′)所示的化合物、其异构体或其药学上可接受的盐。